浙江省2010年含流行性腮腺炎成分疫苗强化免疫效果分析

Effect of a Supplementary Immunization Activity of Mumps-containing Vaccine in Zhejiang Province,2010

目的分析浙江省2010年8月龄-4岁儿童麻疹腮腺炎联合减毒活疫苗（MM）强化免疫（SIA）效果，为流行性腮腺炎（流腮）免疫策略调整提供依据。方法采用描述性方法分析疾病监测信息报告管理系统报告的流腮监测数据。结果浙江省流腮年均报告发病率由SIA前（2004-2010年）的47／10万下降至SIA后（2011-2014年）的28／10万：2011-2014年报告发病率持续下降。年均流腮暴发起数由SIA前的38起下降至SIA后的8起；SIA后5-9岁年龄组（SIA对象）报告发病率由流腮纳入免疫规划（EPI）前（2004～2007年）的418／10万下降至275／10万，但该年龄组报告发病率仍最高。结论MMSIA对流腮防控效果明显，建议全国范围内推行2剂次含流腮成分疫苗的免疫策略，在入小学前完成第2剂次接种。

Objective To analyze the effect of a supplementary immunization activity （SIA） of measles and mumps combined attenuated live vaccine （MM） among children aged 8 months to 4 years in Zhejiang in 2010, and provide evidence for the adjustment of mumps immunization strategy. Methods We ana- lyzed mumps data from the National Notifiable Disease Reporting System using descriptive epidemiological methods. Results The annual reported incidence of mumps in Zhejiang decreased from 47/100 000 in 2004-2010 before the SIA to 28/100 000 in 2011-2014 after the SIA, and the reported incidence contin- ued to decline between 2011 and 2014. The annual average number of outbreaks decreased from 38 in 2004-2010 to 8 in 2011-2014. The reported incidence of mumps among children aged 5-9 years （ the tar- get group of the SIA） declined from 418/100 000 in 2004-2007 to 275/100 000 in 2011-2014, but this age group continued to have the highest incidence among all age groups. Conclusions The SIA with mumps-containing vaccine was effective in controlling mumps. We recommend a 2-dose mumps-contai- ning vaccine immunization strategy nationwide, with the second dose given before primary school.