影响棕色脂肪组织产热活性因素的研究进展

Progress on Factors Affecting Brown Adipose Tissue Thermogenesis Activity

全球性肥胖流行问题愈发严峻,而脂肪组织本身可能是解决这个问题的关键。人和哺乳动物体内存在两种脂肪组织,发挥着截然相反的作用。与白色脂肪组织存储机体过剩的能量不同,棕色脂肪组织中存在独特的解偶联蛋白,能将脂肪酸氧化磷酸化,释放热能,增加能量消耗。因此,通过激活棕色脂肪组织产热,加速体内储存的脂质氧化磷酸化,成为了一种新的预防和治疗肥胖的手段。论文阐述影响棕色脂肪产热活性的因素以及相关机制,旨在为肥胖的治疗提供新的思路和方向。

The global obesity epidemic is increasingly serious, while the adipose tissue itself may be the key to solving it. There are two types adipose tissue in human and mammals,and they play opposite roles. Unlike white adipose tissue stores excess energy, brown adipose tissue has unique uncoupling protein, so it can oxidative phosphorylate fatty acid, then release heat, and increase energy consumption. Therefore, it becomes a new means to prevent and treat obesity by activiting brown adipose tissue thermogenesis, then speeding the oxidative phosphorylation of fat. In present review, we explicated the factors that affect brown adipose tissue thermogenesis activity and related mechanisms, aiming at providing a new method and direction for the treatment of obesity.