肥胖与脂肪组织慢性炎性反应

Obesity and chronic inflammation in adipose tissue

肥胖已成为世界范围内流行性疾病，可导致糖尿病、非酒精性脂肪性肝病及冠心病等相关疾病发生率大大提高。肥胖状态下，脂肪细胞肥大、缺氧状态、内质网应激及脂毒性等会导致脂肪细胞因子功能失调，血管通透性增加，促进免疫细胞浸润到脂肪组织中，释放更多的炎性因子，形成炎性反应的恶性循环，导致慢性炎性状态的持续存在。

Obesity is becoming a prevalent disease in the world, leading to a dramatic increasion of its related disorders including diabetes mellitus, non-alcoholic fatty liver disease as well as cardiovascular disease. The adipocyte hypertrophy, hypoxia, endoplasmic reticulum stress and lipotoxicity are involved in the dysregulation of adipoeytokines and increase of vessel permeability. These factors further facilitate immune cells infiltration to adipose tissues and inflammatory cytokines release. All pathophysiological changes above establish a vicious circle of chronic inflammation in fat tissue, leading to persistent chronic inflammatory state.