肌肉因子与代谢性疾病

Myokines and metabolic disease

近来的研究发现，骨骼肌不仅是人体重要的运动器官，也是活跃的内分泌器官。肌肉因子（myokine）是指由骨骼肌合成、分泌的细胞因子和活性多肽。肌肉因子不仅可以作用于骨骼肌本身，还可通过血液循环到达外周，作用于肝脏、脂肪、心脏等器官，调节机体的代谢。研究表明，肌肉因子与肥胖、2型糖尿病、代谢综合征等代谢相关性疾病的发生、发展密切相关，可能是治疗代谢性疾病的潜在靶点。

Skeletal muscle represents the largest organ of the body in non-obese individuals and is now considered to be an active endocrine organ. Those cytokines and peptides expressed by and released from skeletal muscle have been termed myokines. Myokines have been shown to affect muscle physiology and additionally exert systemic effects on the liver, adipose tissue, brain and other organs. Recent data suggest that myokines may play a key role in the initiation and progression of obesity, type 2 diabetes, metabolic syndrome and other metabolic diseases.