COPD肺心病多器官功能损害

Analysis of multi-organic functional damages in COPD cor pulmonale

目的 :研究COPD肺心病急性加重期多个器官的受损情况。方法 :采用日本OLYMPUS公司AU10 0 0全自动生化分析仪测量 10 9例肺心病急性加重期患者的 17项血生化指标。并与 110例健康体检者进行对照研究。结果 :两组之间血肌酐 (Cr)差异不显著 (P >0 .0 5 ) ,总胆红素 (TBIL)及空腹血糖 (GLU)差异显著 (P <0 .0 5 ) ,其余 14项生化指标P值均 <0 .0 1,两组间差异非常显著。结论 :COPD肺心病急性加重期除了心力衰竭 ,呼吸衰竭之外 ,还常常伴有肝损害、肾损害、高血糖、低脂低胆固醇血症、低蛋白血症及营养不良。保肝护肾 。

Objective: To investigate the damages of multi-organ in the acute aggravating period of COPD cor pulmonale. Methods: Full automatic biochemical analytical instrument (Type AU1000, OLYMPUS Company, Japan) was used to measure 17 blood biochemical indexes in 109 patients in the acute aggravating period of COPD cor pulmonale and 110 healthy controls. Results: Blood creatinine levels were identical between the two groups, while there were obvious differences in TBIL and GLU levels (P<0.05), and very obvious differences in other 14 biochemical indexes (P<0.01). Conclusions: In the acute aggravating period of COPD Cor Pulmonale, except for cardiac and respiratory failures, there existed liver and kidney dysfunction, high blood glucose, low blood fat, cholesterol and protein, and malnutrition. It was very important to protect liver and kidney, maintain blood glucose and fat levels, and provide nutritional support.