抑肽酶对脑肿瘤手术患者血清炎症因子水平的影响

Effect of Aprotinin on Serum Levels of Inflammatory Factors of Brain Tumor Patients Treated with Surgery

目的 探讨抑肽酶应用于脑肿瘤手术的临床效果及其对患者血清炎症因子水平的影响。方法 将56例行脑肿瘤手术患者随机分为观察组和对照组,各28例。观察组于术前12 h~术后24 h给予抑肽酶加入林格氏液静脉滴注,对照组给予单纯林格氏液静脉滴注。比较2组患者的临床疗效以及麻醉诱导前（T_1）、切开硬脑膜（T_2）、术后24 h（T3）的血清TNF-α、IL-6水平。结果 观察组术中出血量、术后脑水肿程度明显低于对照组（P〈0.05）。2组患者T_2、T_3血清TNF-α、IL-6水平明显高于T_1（P〈0.05）,其中观察组升高幅度明显低于对照组（P〈0.05）。结论 抑肽酶应用于脑肿瘤手术中临床效果显著,可减少患者术中出血及术后脑水肿的发生,改善血清TNF-α、IL-6水平,值得推广应用。

Objective To analyze the clinical effect of aprotinin for brain tumor surgery and its effect on serum levels of inflammatory cytokine. Methods 56 patients with brain tumor treated with surgery were randomly divided into the observation group and the control group,28 cases in each. The observation group was given aprotinin in Ringer solution intravenously before surgery after 12 h- 24 h, the control group received intravenous infusion of Ringer＇s solution alone. Clinical efficacy and serum TNF-a, IL-6 levels before induction of anesthesia （ T1 ）, cut the dura （ T2 ）, after 24 h （ T3 ） of the 2 groups were compared. Re- suits Blood loss,postoperative brain edema of the observation group was significantly lower than the control group （P 〈 0.05 ） ; serum TNF-a, IL-6 levels at T2, T3 were significantly higher than T1 （P 〈 0.05 ）, the observation group increased more significant- ly than the control group （ P 〈 0.05 ）. Conclusion Aprotinin used in brain tumor surgery has significant clinical effect, which can effectively reduce blood loss and postoperative patients with cerebral edema,improve serum TNF-a, IL-6 level,it is worthy of clinical application.