结肠癌术后早期腹腔热灌注化疗的疗效分析

Efficacy of Early Hyperthermic Peritoneal Perfusion Chemotherapy for Colon Cancer

目的观察结肠癌术后早期腹腔热灌注化疗的临床效果。方法将90例结肠癌术后患者按随机数字表法分为观察组和对照组,各45例。2组患者术后均进行全身静脉化疗,观察组在术后早期进行腹腔热灌注化疗(continuous hyperthermic peritoneal perfusion chemotherapy,CHPPC)。观察2组患者生活质量、不良反应、肿瘤标志含量、复发、转移以及生存情况。结果观察组术后KPS评分高于对照组(P<0.05)。2组化疗不良反应发生情况差异无统计学意义(P>0.05)。观察组肿瘤标志物含量低于对照组(P<0.05)。观察组复发率和转移率均低于对照组(P<0.05),观察组患者3年生存率明显高于对照组(P<0.05)。结论 CHPPC是结肠癌术后有效的辅助治疗方式。

Objective To observe the clinical effect of early postoperative intraperitoneal perfusion chemotherapy for co- lon cancer patients. Methods 90 patients with colon cancer were randomly divided into the observation group and the control group, with 45 cases in each group. Both groups were treated with intravenous chemotherapy, and the observation group were trea- ted with continuous hyperthermic peritoneal perfusion chemotherapy. Quality of life, adverse reactions, tumor markers, recurrence, metastasis and survival of the 2 groups were observed. Results KPS score in the observation group was higher than that of the control group （P 〈 0.05）, and the adverse reactions of chemotherapy between the 2 groups was not statistically significant （ P 〉 0.05）. The tumor markers in the observation group were significantly lower than those of the control group （ P 〈 0.05 ）. The re- currence rate and metastasis rate in the observation group were lower than those of the control group （P 〈 0.05）. 3-year survival rate in the observation group was significantly higher than that of the control group （P 〈 0.05）. Conclusion Continuous hyper- thermic peritoneal perfusion chemotherapy is an effective adjuvant treatment for colon cancer.