超声引导下注射凝血酶对股动脉假性动脉瘤的治疗效果和安全性

Efficacy and Safety of Ultrasound Guided Thrombin Injection for Femoral Pseudoaneurysms

目的探讨超声引导下注射不同剂量凝血酶治疗股动脉假性动脉瘤的疗效和安全性。方法将80例假性动脉瘤患者随机分为观察组与对照组,各40例。观察组在超声引导下注射100 U/ml凝血酶,对照组在超声引导下注射500 U/ml凝血酶。对2组患者一般治疗情况、疗效及不良反应发生情况进行对比。结果 2组平均操作时间及凝血酶注射次数无统计学差异(P>0.05),而观察组凝血酶注射总量远小于对照组,差异有统计学意义(P<0.05)。治疗后观察组总有效率为97.5%,对照组总有效率为100.0%,2组差异无统计学意义(P>0.05)。对照组不良反应发生率远高于观察组,差异有统计学意义(P<0.05)。结论超声引导下注射小剂量凝血酶对股动脉假性动脉瘤的治疗有积极的效果,且不良反应较少,值得临床推广应用。

Objective To explore the efficacy and safety of ultrasound guided thrombin injection for femoral pseudoaneu- rysms. Methods 80 cases with femoral pseudoaneurysms were selected and randomly divided into the observation group and the control group, with 40 cases in each. The observation group was given 100 U/mL thrombin, and control group was given 500 U/mL thrombin guided by ultrasound. Then the general treatment, efficacy and adverse reaction of the 2 groups were observed and com- pared. Results The average injection time and the times of the 2 groups were almost the same （P 〉 0.05）, but the total amount of the observation group was obviously lower than that of the control group, there had statistical difference （ P 〈 0.05 ）. The total efficacy of the observation group was 97.5%, and the control ,group was 100.0%, there had no statistically difference （ P 〉 0.05）. The adverse reactions rate of the control group was higher than that of the observation group （P 〈 0.05 ）. Conclusion Ultrasound guided injection with small dose of thrombin has good effect for femoral pseudoaneurysms,with less adverse reaction, and it is worthy of clinical application.