生物羊膜移植在原发性青光眼小梁切除术中的临床观察

Clinical observation of biological amniotic membrane transplantation in trabeculectomy of primary glaucoma

目的对比分析生物羊膜移植联合小梁切除术在治疗原发性青光眼中的安全性和有效性。方法对已进行生物羊膜移植联合小梁切除术（第1组）98例（112只眼）和常规小梁切除术（第2组）80例（102只眼）已确诊的原发性青光眼患者进行分析。术后随访6-12个月,平均7个月。结果第1组和第2组的术后6个月及1年的眼压控制率、浅前房发生率、功能性滤过泡比例、使用抗青光眼药物数量减少,差异有统计学意义（P〈0.05）。结论对于原发型青光眼（开角型和闭角型）第1组与第2组比较,生物羊膜移植联合小梁切除术在术后滤过泡形成、防止术后浅前房和控制眼压及使用抗青光眼药物数量减少方面均优点明显。

Objective To comparatively analyze the safety and efficacy of biological amniotic membrane transplantation combined trabeculectomy in the treatment of primary glaucoma. Methods Retrospective case series. For biological amniotic membrane transplantation has combined trabeculectomy （group 1 ）, 98 cases （112 eyes） and routine trabeculectomy （group 2）, 80 cases （ 102 eyes） confirmed primary glaucoma patients were analyzed. Followed up for 6 to 12 months postoperatively, 7 months on average. Results The result of group 1 and group 2 of 6 months and 1 year after intraocular pressure control, the incidence of shallow anterior chamber, the proportion of functional fihering bleb, use the decrease in the number of glaucoma medications, the difference was statistically significant. Conclusion For the original hairstyle （open Angle glaucoma and primary closed -angle） compared with group 2, group 1 biological amniotic membrane transplantation combined trabeculectomy in postoperative filtering bleb formation, prevent postoperative shallow anterior chamber and intraocular pressure control and the use of the decrease in the number of glaucoma medications advantages are obvious.