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食管鳞癌患者血清组织蛋白酶X水平检测及其临床意义

Clinical significance of serum Cathepsin X levels in patients with esophageal squamous cell carcinoma
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摘要 目的研究血清组织蛋白酶X(Cathepsin X,Cat X)在食管鳞癌中的临床意义。方法应用酶联免疫吸附技术(enzyme linked immunosorbent assay,ELISA)检测65例食管鳞癌患者、35例健康体检者中血清Cat X的含量,分析血清Cat X的表达水平与食管鳞癌患者临床病理特征之间的关系。结果食管鳞癌患者血清Cathepsin X水平明显高于健康体检者(P<0.01),食管鳞癌患者血清Cathepsin X水平的高低与食管鳞癌的分期、淋巴结转移情况显著相关(P<0.05)。结论血清Cat X可能成为一种新的肿瘤标志物,有助于食管鳞癌的早期诊断、预后预测,以及侵袭转移情况的判断。 Objective To investigate the clinical significance of serum Cathepsin X in esophageal squamous cell carcinoma. Methods Levels of serum Cat X in 65 cases of esophageal squamous cell carcinoma patients and 35 cases of healthy persons was determined by ELISA, and to analyze the relationship between the expression level of serumCatX and the clinicopathologicalfeatures of esophageal squamons cell carcinoma patients. Results The level of serum Cathepsin X in patients with esophageal squamous cell carcinoma was significantly higher than that in healthy subjects （P 〈 0. 01 ）, and the level of serum Cathepsin X in patients with esophageal squamous cell carcinoma was significantly correlated with the stage of esophageal squamous cell carcinoma and lymph node metastasis（ P 〈0. 05 ）. Conclusion Serum Cat X might serve as a new tumor marker, which is helpful for the early diagnosis, prognosis prediction, and the judgment of the invasion and metastasis of esophageal squamous cell carcinoma.
作者 周晓佳 张炳勇 张艳玲 白阳秋
机构地区 郑州大学人民医院消化内科
出处 《医药论坛杂志》 2016年第6期17-19,共3页 Journal of Medical Forum
关键词 CathepsinX 食管鳞癌 血清 ELISA CathepsinX Esophageal squamous cell carcinoma Serum ELISA
分类号 R735.1 [医药卫生—肿瘤]
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参考文献14

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医药论坛杂志
2016年 第6期

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