感染性腹泻患儿内皮素、D-二聚体及纤维蛋白原水平变化观察

Changes of endothelin, D-dimer and fibrinogen levels in children with infectious diarrhea

目的 研究分析感染性腹泻患儿内皮素、D-二聚体和纤维蛋白原水平的变化情况.方法 选取2013年7月至2015年7月收治的感染性腹泻患儿75例,按照病情分为轻型组25例、中型组25例、重型组25例,另选取同期进行健康检查的婴幼儿25例为对照组,对比四组内皮素（ET）、D-二聚体（D-D）、纤维蛋白原水平（FBG）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）和凝血酶时间情况（TT）.结果 中型组、重型组ET、D-D、FBG水平明显高于轻型组和对照组,差异有统计学意义（P＜0.05）;重型组ET、D-D、FBG水平明显高于中型组,差异有统计学意义（P＜0.05）;四组PT、APTT和TT等指标比较差异未见统计学意义（P＞0.05）.结论 感染性腹泻患儿腹泻程度越严重,其内皮素、D-二聚体和纤维蛋白原水平越高,血管内皮细胞功能越加紊乱.

Objective To investigate and analyze the changes of endothelin,D-dimer and fibrinogen levels in children with infectious diarrhea.Methods From July 2013 to July 2015,75 children with infectious diarrhea were divided into mild group,medium-sized group and severe group,with 25 cases in each group,while 25 cases of healthy infants were selected as the control group.The levels of endothelin,D-dimer,fibrinogen level,prothrombin time,activated partial thromboplastin time and thrombin time situation among the four groups were compared.Results The levels of FBG,D-D and ET were significantly higher in the medium-sized and severe groups than those in the mild and control groups,the differences were significant （P 〈 0.05）;the levels of FBG,D-D and ET in the severe group were significantly higher than those in the medium-sized group,the differences were significant （P 〈 0.05）.There was no significant difference in the levels of PT,APTT or TT among the 4 groups （P 〉 0.05）.Conclusions The severity of diarrhea in children with infectious diarrhea,the higher the level of endothelin,D-dimer and fibrinogen,and the severer dysfunction of vascular endothelial cells.