功能性细胞获得的研究进展及应用前景

Progress and prospect on obtaining functional cells

细胞移植可以修复和治疗人体损伤及功能性障碍的组织器官,但体内分离获得可以用于治疗相应疾病的功能性细胞在来源和数量上受到极大限制。因此,如何在体外获得合适的功能性细胞成为重要的科学问题。目前,体外功能性细胞的获得取得了突破性进展。现主要对体外通过胚胎干细胞/诱导多能干细胞分化或体细胞间转分化获取的功能性细胞的研究进展及应用前景进行综述,以期进一步推动我国在功能性细胞获得的基础研究及临床转化。

Damage and functional disorder in human tissues/organs could be treated by cell transplantation. However, the functional cells for transplantation isolated in vivo are limited by the source and amount. How to obtain the suitable functional cells in vitro for treatment became the key question here. Currently, lots of important progresses have been achieved in producing the functional cells in vitro. The review mainly focuses on the progress and prospect of the functional cells differentiated from embryonic stem cells/induced pluripotent stem cells or transdifferentiated from other somatic cells, which may promote the further study and clinical transformation.