3,4-二羟基-5-甲氧基苯甲酸甲酯合成方法的改进

Improvement on Synthesis Technology of 3,4-Dihydroxy-5-Methoxy Methyl Benzoate

通过对3,4-二羟基-5-甲氧基苯甲酸甲酯在超声波辅助下合成工艺条件的研究,在单因素试验和正交试验的基础上,探讨了反应温度、时间、功率、催化剂四个因素对目标产物产率的影响。结果表明:以没食子酸和甲醇为原料,浓硫酸为催化剂,碳酸二甲酯为甲基化试剂,超声反应时间为3h,超声功率为95W,水浴温度为70℃,总产率可达48.6%。此工艺能够缩短时间,减少污染,提高产率。

By studying assisted synthesis of 3,4-dihydroxy-5-methoxy methyl benzoate on the Ultrasonic,this article,on the basis of single factor extraction test and orthogonal test,discusses the effect of various reaction conditions on yield investigated,such as ultrasonic radiation power,temperature,time,catalyst and so on.Experimental results show the best condition that when the reaction time is 3h,ultrasonic radiation power is 95 W,bath temperature is 70 ℃,sulfuric acid as catalyst,dimethyl carbonate as methylating reagent,gallic acid and methanol as raw materials,the yield can be up to 48.6%.This process is faster,more efficient and has less pollution under the ultrasonic radiation.