摘要
成功构建了包括新型卤代醇、羟基氰、芳香醇、脂肪醇和芳香胺的手性砌块库,涵盖108种手性化合物。构建了5种新型酶-化学手性反应模块,例如脂肪酶拆分-Pd/LDH-DS消旋反应模块能够在常温下拆分芳香胺类,其中底物转化率99%,产物ee值99%,突破生物拆分过程理论转化率仅为50%的不足,过程的原子经济性与转化效率较高,具有较大的创新性。
A chiral block library,including 108 kinds of chiral chemicals,were constructed.5 types of novel chem-enzymatic synthesis modules were also developed.For example,the module of lipase coupled with Pd/LDH-DS was successfully used in the resolution of aromatic amine with the excellent results of conversion of 99% and eep of 99%.The atom economy and conversion efficiency were greatly improved with this novel module.
作者
杨立荣
吴坚平
岑琦琼
Yang Lirong Wu Jianping Cen Qiqiong(Zhejiang Universit)
出处
《科技创新导报》
2016年第16期181-181,共1页
Science and Technology Innovation Herald
关键词
手性砌块
合成模块
库
化学-酶法
脂肪酶
拆分
Chiral block
Synthesis module
Library
Chem-enzymatic method
Lipase
Resolution
