白念珠菌唑类药物相关耐药基因及其调控机制的研究进展

Drug resistance genes of Candida albicans to azoles and their regulation mechanisms

白念珠菌是人体常见的条件致病性真菌。随着唑类抗真菌药物的长期、广泛应用,白念珠菌耐唑类抗真菌药物的临床分离株也逐渐增多,已经成为临床抗白念珠菌治疗的棘手问题。现就白念珠菌唑类药物相关耐药基因及其调控机制进行综述,以便在转录调控层面寻找新的白念珠菌感染的治疗靶点及开发新的抗真菌药物。

Candida albicans is a conditionally pathogenic fungus in human. With azoles being widely applied for a long time,the clinical isolates of Candida albicans against azoles gradually increase. The clinical treatment of Candida albicans has become a thorny issue. The drug resistance genes of Candida albicans and regulation mechanisms are reviewed for finding new therapeutic targets and developing new antifungal agents at the level of transcriptional regulation.