银杏蜜环口服液对不稳定型心绞痛病人CRP、E-SOD、P-LPO、E-LPO的影响

Effects of Ginkgo Mihuan Oral Liquid on CRP,E-SOD,P-LPO,E-LPO and Other Indexes in Patients with Unstable Angina Pectoris

目的观察银杏蜜环口服液对不稳定型心绞痛病人C反应蛋白(CRP)、血浆过氧化脂质(P-LPO)、红细胞超氧化物歧化酶(E-LPO)等指标水平的变化。方法选取辽宁中医药大学附属医院、辽宁电力中心医院、大连市中医医院三所医院前来就诊住院的160例不稳定型心绞痛病人,根据病情、病程、年龄及性别等因素采用分层随机法分为对照组和观察组,每组80例。两组均给予西医常规对症治疗,观察组在常规对症治疗的基础上给予银杏蜜环口服液(每次10mL,一日3次)口服。治疗疗程为4周。分别于治疗前后观察心电图及临床症状改变,检测血清蛋白CRP,E-SOD平均活性P-LPO、红细胞过氧化脂质(E-LPO)、肱动脉内皮依赖性舒张功能(FMD)、内皮素(ET-1)、一氧化氮(NO)、血栓素B_2(TXB_2)以及6-酮-前列腺素Fla(6-keto-PGF-1α)水平变化,并进行临床疗效评价。结果治疗后,两组各指标均有所改善,观察组CRP、P-LPO、E-LPO、ET-1、TXB_2水平明显下降(P<0.05或P<0.01),E-SOD、FMD、NO、6-Keto-PGF-lα水平明显升高(P<0.05或P<0.01),与对照组比较具有统计学意义(P<0.05或P<0.01)。观察组组总有效率为88.75%,明显高于对照组67.50%(P<0.05)。结论银杏蜜环口服液联合西医常规对症治疗能有效改善不稳定型心绞痛临床症状,改善血液流变学指标水平、改善血管内皮功能的作用,提高临床综合疗效。

Objective To observe the effects of Ginkgo Mihuan oral liquid（GMOL）on serum C reactive protein（CRP）,plasma lipid peroxide（P-LPO）,erythrocyte lipid peroxide（E-LPO）and other indexes in patients with unstable angina pectoris（UAP）.Methods One hundred and sixty patients with UAP in the Third Affiliated Hospital of Liaoning University of traditional Chinese medicine,Liaoning Electric Power Center Hospital,Dalian Hospital of Traditional Chinese Medicine,according to the illness,disease,age,and sex factors using a stratified random method were divided into two groups：control group（n =80）treated with routine treatment,and treatment group（n =80）treated with GMOL plus routine treatment for 4 weeks.Before and after the treatment,the electrocardiographic and clinical symptoms,the levels of serum CRP,and erythrocyte superoxide dismutase（E-SOD）average activity and P-LPO,E-LPO,brachial artery street endothelial dependent diastolic function（FMD）,endothelin（ET-1）,nitric oxide（no）and thromboxane B2（TXB2）and 6-ketoprostaglandin fla 6-keto-PGF-1α,and clinical efficacy were observed.Results After the treatment,the indexes were improved in two groups.Compared with the control group,the levels of serum CRP,P-LPO,E-LPO,ET-1 and TXB2 decreased significantly in treatment group（P〈0.05 or P〈0.01）while E-SOD,FMD,NO,6-keto-PGF-1αlevels increased significantly（P〈0.01）.The total efficiency was 88.75%in treatment group,which was higher than that in control group（67.50%,P〈0.0 5）.Conclusion GMOL and routine treatment can effectively improve the clinical symptoms,hematological indexes level,improve vascular endothelial function and the overall efficacy in patients with UAP.