中老年男性2型糖尿病患者中血尿酸与血压的关系探讨

Relationship between serum uric acid and blood pressure in elderly male patients with type 2 diabetes mellitus

目的 探讨中老年男性2型糖尿病（T2DM）患者血尿酸（SUA）与血压及相关代谢指标的相关性。方法 收集北京市东四社区于2012年5月-2013年8月常规查体人群576例临床资料进行单中心横断面研究。测定身高、体质指数（BMI）、血糖、血压、SUA等指标,将SUA水平按四分位分组,用t检验或方差分析比较不同分组间各因素差异,用logistics回归分析比较SUA与收缩压（SBP）、舒张压（DBP）及相关指标关系,P〈0.05为差异有统计学意义。结果 本研究人群中血压异常发病率在不同SUA水平中分别为：37%（50/135）,47.2%（68/144）,47.6%（72/151）和56.8%（83/146）;相关性研究结果显示SBP均随着SUA浓度升高而升高,两者呈正相关关系（P〈0.05）,而DBP与SUA无明显相关性（P〉0.05）。结论 中老年男性T2DM患者中,SUA水平与SBP明显正相关,而与DBP未见明显相关,提示SUA水平与T2DM患者血压中的收缩压密切相关。

Objective To investigate the relationship between serum uric acid（SUA） and blood pressure and related metabolic indexes in elderly men with type 2 diabetes mellitus（T2DM）. Methods The clinical data of 576 cases who were in community from August 2013 to May 2012,was collected for cross-sectional survey. Height, body mass index（BMI）, blood glucose, blood pressure, SUA and other indicators were gathered. According to the SUA level, the data were divided into four groups, and T test or analysis of variance was used to evaluate the differences among four groups. Logistics regression analysis was used to find out the relationship between SUA, systolic blood pressure（SBP）, diastolic blood pressure（DBP） and related indexes. P〈0.05 was considered to be statistically significant. Results In this study, the incidence of abnormal blood pressure in different levels of SUA were 37%（50/135）, 47.2%（68/144）, 47.6%（72/151）, and 56.8%（83/146）. The results showed that SBP increased with the increasing level of SUA and they had a positive correlation（P〈0.05）, but there was no significance correlation between DBP and SUA（P〉0.05）. Conclusion SBP is significantly positively correlated with the level of SUA, but DBP has no significant correlation with the level of SUA. The results indicate that the level of SUA is closely related with the SBP in patients with T2DM.