摘要
目的:研究miRNA-99b(miR-99b)在新辅助化疗宫颈癌组织中的表达。方法:宫颈癌患者55例分别于新辅助化疗前后收集肿瘤组织标本行micRNA的提取、反转录、实时定量PCR检测miR-99b的表达。结果:宫颈癌新辅助化疗后miRNA99b表达显著上升,与治疗前表达比较有统计学差异(P<0.05)。结论:新辅助化疗可通过上调miRNA-99b表达,实现对宫颈癌的抑制。
Objective：To study the expression of the miR-99 bbefore and after neo adjuvant chemotherapy of cervical cancer.Methods：Through micRNA extraction,reverse transcription,timing quantitative PCR detection the expression of miR-99 bin the tumor tissue respectively before and after neoadjuvant chemotherapy in the patients with cervical cancer.Results：After neoadjuvant chemotherapy the cervical cancer miR-99 bexpression was significantly higher（P〈0.05）.Conclusion：Neoadjuvant chemotherapy can inhibition of cervical cancer through raising the expression of the miR-99 b.
出处
《陕西医学杂志》
CAS
2016年第10期1292-1293,1312,共3页
Shaanxi Medical Journal
基金
陕西省社发攻关资助项目(2010K01-156)
