成年人支原体肺炎合并病毒感染者细胞因子表达研究

Cytokines expression of mycoplasma pneumoniae and virus co-infections in adults with community acquired pneumonia

目的:探讨成年人支原体肺炎合并病毒感染者血清促炎及抗炎细胞因子表达水平变化。方法:75例成年人支原体肺炎患者按照是否合并病毒感染分为单一支原体感染和合并病毒感染两组。检测并比较支原体肺炎患者及12例健康对照组的血清中促炎细胞因子和抗炎细胞因子水平变化。结果:75例支原体肺炎患者中,合并病毒感染者19例(25.33%)。与对照组比较支原体肺炎患者急性期血清中促炎和抗炎细胞因子水平均明显升高,支原体肺炎合并病毒感染患者MCP-1和IL-8水平明显高于单一支原体感染患者(P<0.05)。结论:成年人支原体肺炎合并病毒感染者血清促炎细胞因子MCP-1和IL-8表达显著升高,提示混合感染者存在更加严重的炎症反应。

Objective：To investigate pro-inflammatory and anti-inflammatory cytokines expression level of adult Mycoplasma pneumoniae（MP）pneumoniapatients who co-infected with viruses.Methods：75 cases of adult MPpneumonia patients were divided into the single MP infection group and co-infection group.Levels ofPro-inflammatory cytokinesand anti-inflammatory cytokines in patients and healthy controls were quantified and compared.Results：Among 75 adult MP pneumonia patients,the incidence rate of co-infection with viruses was 25.3%（n=19）.Pro-inflammatory and anti-inflammatory cytokine levels were significantly increased in MP pneumonia patients compared with healthy controls.And the MCP-1 and IL-8 levels were higher in virus co-infection patients than those in single MP infection（P〈0.05）.Conclusion：The level of MCP-1 and IL-8 in MP and virus co-infection pneumonia patients increased significantly,suggesting thatMP pneumonia patients co-infected with viruses exists more serious inflammation response.