异甘草酸镁治疗慢性乙肝及对患者Th1/Th2型细胞因子的影响

The effect of magnesium isoglycyrrhizinate on chronic hepatitis B and Th1/Th2 cytokines of the patients

目的探讨异甘草酸镁治疗慢性乙肝及对患者Th1/Th2型细胞因子的影响。方法选取2013年12月至2014年12月我院收治的慢性乙肝患者80例作为研究对象,将其随机分为对照组和观察组。对照组给予常规治疗,观察组患者给予异甘草酸镁治疗。结果观察组治疗总有效率(77.50%)高于对照组的(55.00%)(P<0.05)。治疗后,两组ALT、AST水平与治疗前相比均有所降低,且观察组患者AST水平(42.2±6.1)U/L、ALT水平(41.7±6.6)U/L均低于对照组AST水平(52.9±7.2)U/L、ALT水平(51.5±8.3)U/L(P<0.01)。治疗后,两组IFNγ、IL-2、IL-4、IL-10水平与治疗前相比均有所改善,且观察组治疗后IFNγ水平(29.29±10.07)pg/m L、IL-2水平(196.36±10.53)pg/m L、IL-4水平(45.78±11.04)pg/m L、IL-10水平(8.47±6.14)pg/m L改善程度均优对照组IFNγ水平(18.33±9.14)pg/m L、IL-2水平(143.21±12.74)pg/m L、IL-4水平(75.23±12.75)pg/m L、IL-10水平(13.91±6.42)pg/m L,差异具有统计学意义(P<0.01)。结论异甘草酸镁治疗慢性乙肝能有效提高患者的治疗效果,促进肝功能的恢复,改善机体免疫紊乱状态,减轻机体炎症反应。

Objective To explore the effect of magnesium isoglycyrrhizinate on the treatment of chronic hepatitis B and Th1/Th2 cytokines of these patients. Methods Eighty patients with chronic hepatitis B in our hospital from December 2013 to December 2014 were selected as the research objects, and they were randomly divided into control group and observation group. Patients in the control group received conventional treatment, whereas those in the observation group were treated with magnesium Isoglycyrrhizinate. Results The total effective rate in the observation group （77.50%） was significantly higher than that in the control group （55%） （P 〈 0.05）. After treatment, the levels of AST and ALT were reduced in both groups. The levels of AST （42.2 ± 6.1 ）U/L and ALT （41.7 ± 6.6）U/L in the observation group were significantly lower than AST （52.9 ±7.2）U/L and ALT （51.5 ± 8.3）U/L in the control group （P 〈 0.01）. However, the levels of IFNy, IL-2, IL-4 and IL-10 were improved in both groups after treatment. The levels of IFN-γ （29.29 ± 10.07）pg/mL, IL-2 （196.36 ± 10.53）pg/mL, IL-4 （45.78 ± 11.04）pg/mL and IL-10 （8.47 ± 6.14） pg/mL were better than that in the control group, which was （18.33 ± 9.14）pg/mL, （143.21 ± 12.74）pg/mL, （75.23 ± 12.75）pg/mL and （13.91 ± 6.42）pg/mL, respectively; the differences were also statistically significant （P 〈 0.01）. Conclusion Magnesium isoglycyrrhizinate could effectively increase the efficacy in the treatment of chronic hepatitis B, enhance the recovery of liver function, improve the immune state, and reduce inflammatory reaction.