蒙脱石散联合双歧杆菌四联活菌片对儿童腹泻肠黏膜5-HT和血浆NPY、VIP的影响被引量：20

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摘要目的研究蒙脱石散联合双歧杆菌四联活菌片对儿童腹泻肠黏膜5-羟色胺(5-HT)和血浆神经肽Y(NPY)血管活性肽(VIP)的影响。方法选择西安济仁医院进行诊治的腹泻患儿80例,随机分为两组,对照组予以口服蒙脱石散治疗,观察组予以蒙脱石散联合双歧杆菌四联活菌片治疗,观察两组的临床症状和疗效,并检测肠黏膜5-HT和血浆NPY、VIP水平。结果观察组的有效率为90.0%,明显高于对照组的72.5%(P<0.05);观察组的腹泻次数正常时间、大便性状变稠时间、腹痛停止时间、腹泻停止时间、大便细菌培养恢复正常时间和大便镜检正常时间均明显短于对照组(P<0.05);治疗3 d后,两组肠黏膜5-HT和血浆VIP水平明显降低(P<0.05),血浆NPY明显升高(P<0.05),而观察组的改善程度明显优于对照组(P<0.05)。结论蒙脱石散联合双歧杆菌四联活菌片能明显降低腹泻患儿肠黏膜5-HT和血浆VIP水平,促进血浆NPY的生成,改善临床症状,缩短治疗时间,提高治疗效果,值得应用推广。

作者张小军赵国栋邢军卫

机构地区西安济仁医院儿内科西安交通大学第一临床医学院

出处《现代消化及介入诊疗》 2016年第4期587-589,共3页 Modern Interventional Diagnosis and Treatment in Gastroenterology

关键词蒙脱石散双歧杆菌四联活菌片 5-羟色胺神经肽Y 血管活性肽

分类号 R725.7 [医药卫生—儿科]

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