GnRHa、hCG在促排卵治疗多囊卵巢综合征不孕患者中的应用效果比较

Comparison of the effects of GnRHa and hCG in the treatment of PCOS infertility patients with ovulation induction

目的:探讨促性腺激素释放激素激动剂(GnRHa)、人绒毛膜促性腺激素(h CG)在多囊卵巢综合征(PCOS)不孕患者的促排卵治疗中诱导卵泡成熟及排卵的应用效果比较。方法:依据纳入标准选取接受促排卵治疗的PCOS不孕患者(101例),将研究对象随机分成两组,GnRHa组(49例)和h CG组(52例),分别使用GnRHa(天兴0.1mg)、h CG(10 000 IU)诱发排卵。通过两组患者的血清FSH、LH、E2水平、卵巢过度刺激综合征(OHSS)的发生率、未破裂卵泡黄素化综合征(LUFS)发生率、妊娠率、多胎妊娠率、早期流产率和未孕患者的下次月经期囊肿发生率,比较GnRHa、h CG诱导卵泡成熟及排卵作用在促排卵治疗中的应用效果。结果:GnRHa组与h CG组的FSH、LH、E2水平比较,差异无统计学意义(P>0.05);未破裂卵泡黄素化综合征(LUFS)发生率、妊娠率、多胎妊娠率、早期流产率比较,差异无统计学意义(P>0.05);GnRHa组OHSS发生率及下次月经期囊肿发生率均低于h CG组,差异有统计学意义(P<0.05)。结论:促排卵治疗PCOS不孕症患者,曲普瑞林可以代替h CG诱导卵泡成熟及排卵,并且给予常规黄体支持方案不影响其妊娠结局。

Objective To explore the effect of GnRHa and h CG used in ovulation induction treatment in patients with PCOS. Method Totally 101 PCOS infertility patients in ovulation induction treatment were chosen according to the Inclusion criteria. The participants into two groups at random,Group GnRHa（ 49 cases） took GnRHa 0. 1mg and Group h CG（ 52 cases） took h CG 10 000 IU for trigger. Patients＇ serum FSH,LH,E2 level,ovarian hyperstimulation syndrome（ OHSS） rate,luteinized unruptured follicle rate,pregnancy rate,Multiple pregnancy rate,early abortion rate and next cycle cysts incidence of unfertilized patients were compared between the two groups. Results There were no significant in Serum hormone level,luteinized unruptured follicle rate,pregnancy rate,multiple pregnancy rate,early abortion rate between the two groups（ P〉0. 05）,OHSS rate and next cycle cysts incidence were significant lower in group GnRHa than that in group h CG（ P〈0. 05）. Conclusion GnRHa can apply to trigger in intraine insemination in patients with PCOS,and conventional luteal support scheme didn＇t affect the pregnancy out-come.