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莫达非尼对嗜睡患者疗效的系统评价和Meta分析

Effect of hypersomnia patients with modafinil system evaluation and Meta analysis
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摘要 目的:通过对莫达非尼在嗜睡患者的应用,评价其治疗效果。方法:检索计算机英文数据库Pubmed、Embase、Cochrane图书馆,纳入莫达非尼对嗜睡患者的随机对照试验,采用Rev Man5.3进行Meta分析。结果:纳入研究4项,共132例患者。Meta分析结果显示,莫达非尼治疗嗜睡的临床治愈率差异有统计学意义(χ2=1.68,P<0.05)。结论:莫达非尼能在一定程度上改善嗜睡患者的睡眠。 Objective To assessment the treatment efficacy of modafinil versus placebo for hypersomnia. Method A systematic review of randomized controlled trials with meta- analysis by searching databases of Pub Med,EMBASE and the Cochrane Central. Randomized controlled trials comparing modafinil and placebo therapies in hypersomnia patients. Results Four trials were analyzed,132 patients involved. Meta- analysis showed that modafinil for clinical cure rate in hypersomnia patients（ χ^2= 1. 68,P〈0. 05）. Conclusion Modafinil is effective for treatment of hypersomnia patients.
作者 胡容 熊钰 李星凤 周恩 贺艳
机构地区 湖南师范大学医学院 湖南师范大学第二附属医院
出处 《吉林医学》 CAS 2016年第10期2457-2459,共3页 Jilin Medical Journal
关键词 莫达非尼 嗜睡 随机对照 系统评价 Modafinil Hypersomnia Randomized controlled Systematic review
分类号 R740 [医药卫生—神经病学与精神病学]
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参考文献13

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吉林医学
2016年 第10期

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