不同剂量琥珀酸美托洛尔对慢性心力衰竭患者血清NT-proBNP水平的影响

Effect of different dose of metoprolol on serum NT-proBNP levels in patients with chronic heart failure

目的:探讨不同剂量琥珀酸美托洛尔对慢性心力衰竭(CHF)患者血清NT-pro BNP水平的影响。方法:将CHF患者60例随机分为观察组和对照组,对照组给予低剂量琥珀酸美托洛尔(>95mg/d)治疗,观察组给予高剂量琥珀酸美托洛尔治疗(≤95 mg/d),观察其对患者血清NT-pro BNP水平等指标影响。结果:观察组患者治疗后3个月、6个月及1年后血浆NT-pro BNP水平明显低于对照组(P<0.05)。观察组患者治疗后1年6min步行距离明显优于对照组(P<0.05)。观察组患者治疗后血压、心率与对照组比较,差异无统计学意义(P>0.05)。观察组患者治疗后1年LVEF值及NYHA分级明显优于对照组(P<0.05)。结论:高剂量的琥珀酸美托洛尔降低CHF患者血清NT-pro BNP水平作用更强,安全可靠,值得应用。

Objective To investigate the effects of different dose of metoprolol succinate on serum NT pro BNP levels in patients with chronic heart failure（ CHF）. Method 60 cases of patients with CHF were randomly divided into the observation group and the control group,the control group was treated with Low Dose Metoprolol（ 95 mg / d） in treatment,and the observation group was given the high dose metoprolol in treatment（ ≤95 mg / d）,the influences of serum NT- pro BNP levels and other indicators was evaluated. Results After 3 months,6 months and 1 years after treatment,the plasma NT- pro BNP levels in the observation group were significantly lower than those in the control group（ P〈0. 05）. The 6 min walking distance in observation group patients after 1 years was significantly better than the control group（ P〈0. 05）. The blood pressure and heart rate level in observation group after treatment were same to the control group,and there was not statistically significant difference（ P〈0. 05）. The LVEF and NYHA grade of the observation group were significantly better than those of the control group after treatment for1 years（ P〉0. 05）. Conclusion The high dose of metoprolol succinate reduced more in the role of serum NT- proB NP level in patients with CHF,and it is safe and reliable,so it is worthy of application.