养肝化瘀汤治疗乙型肝炎代偿期肝硬化气虚血瘀证的临床疗效分析

Analysis of Clinical Efficacy of Huayu Decoction in the Treatment of Hepatitis B Liver Cirrhosis with Qi Deficiency and Blood Stasis

目的探讨养肝化瘀汤治疗乙型肝炎代偿期期肝硬化的临床疗效。方法方便选取该院自2010年9月—2015年12月住院的60例乙型肝炎代偿期肝硬化患者,随机分为治疗组(30例)和对照组(30例),治疗组给予养肝化瘀汤,对照组给予还原性谷胱甘肽片,疗程3个月,观察治疗前后两组B超检查结果、肝功能、肝纤维化指标治疗前后改善情况。结果治疗组总有效率为80%优于对照组总有效率为66.7%(P<0.05);经治疗后,治疗组HA、PⅢP、LN、ALT、A ST、Ⅳ-C分别为(65.57±9.838)μg/L、(14.40±9.543)n/g、(115.95±39.792)k Da、(54.44±32.713)pmol/L、(51.52±31.245)IU/L、(47.13±13.329)ng/m L优于对照组(P<0.05);B超结果比较,治疗前后,两组间差异有统计学意义(P<0.05)。结论养肝化瘀汤在一定程度上可减小门静脉内径、脾脏厚度,优于单纯用还原型谷胱甘肽治疗。

Objective To investigate the clinical effect of Huayu Decoction in the treatment of decompensated liver cirrhosis of hepatitis B. Methods Convenient selection to our hospital since September 2010 to December 2015 my division hospitalization of 60 cases of decompensated hepatitis B cirrhosis patients were randomly divided into the treatment group（30cases） and control group（30 cases）, the treatment group give Yanggan decoction, the control group was treated with reduced glutathione tablets, treatment for 3 months observed before and after treatment in two groups the results of ultrasonic examination, liver function, hepatic fibrosis indexes before and after treatment to improve the situation. Results The treatment group total effective rate was 80% higher than control group, the total effective rate was 66.7%（P〈0.05）; after treatment,treatment group HA, P IIIP, LN, ALT, AST, IV-C were（65.57 ± 9.838） μg/L,（14.40± 9.543） n/g,（115.95 ± 39.792） k Da,（54.44 ± 32.713） pmol / L,（51.52 ± 31.245） IU/L,（47.13±13.329） ng/m L is better than that of the control group（P〈0.05）;ultrasound results, before and after the treatment, between the two groups have significant difference（P〈0.05）. Conclusion Yanggan Decoction in a certain extent can be reduced wicket vein, thickness of spleen, is better than that only using glutathione therapy.