儿童胆汁淤积性肝病172例临床分析

Cholestasis Liver Disease in Children, 172 Cases of Clinical Analysis

目的探讨儿童胆汁淤积性肝病的病因、临床表现、辅助检查及预后并进行分析。方法方便选取2011年4月—2015年6月在该院治疗的172例患有胆汁淤积性肝病儿童的病历资料,对其进行分析。结果对各种病因的儿童患者进行统计发现,造成儿童胆汁淤积的原因主要原因有胆道闭锁造、CMV感染造成、PNAC、胆总管囊肿以及其他原因。胆道闭锁占有比例最高。A组为胆道闭锁组,其白便表现高于C组(P<0.05);C组其他病因组早产因素总体大于A组。使用GGT值>50 U/L以及彩超诊断胆道闭锁具有一定优势(P<0.05)。C组病情好转率大于A组(P<0.05)。结论儿童胆汁淤积性肝病病因复杂,临床表现多样,对辅助检查的敏感性不同,预后与病因有一定关系。

Objective To investigate the child cholestatic liver disease etiology, clinical manifestations, laboratory examination and analysis and prognosis. Methods Convenient selection children with cholestatic liver disease in the medical records of 172 cases from April 2011 to June 2015 in our hospital, and analyze them. Results Children with various causes of statistics found that the reasons causing children cholestasis main reasons biliary atresia made, CMV infection causes,PNAC, bile duct cysts and other reasons. It occupies the highest proportion of biliary atresia. A group of biliary atresia group, outperformed their white group C（P〈0.05）; group C Other causes preterm A factor greater than the overall group. Use GGT values 〉50 U / L and color Doppler ultrasound diagnosis of biliary atresia has certain advantages（P〈0.05）. Group C improvement rates higher than A group（P〈0.05）. Conclusion Children cholestatic liver disease of complex etiology, clinical manifestations, laboratory examinations different sensitivity of the prognosis and etiology of certain relationships.