甲强龙与头孢替安联合依匹斯汀治疗白细胞升高性急性荨麻疹疗效分析

Curative Efficacy Analysis of Methylprednisolone and Cefotiam Combined with Epinastine in Treating Acute Urticaria with Increase in Leucocytes

目的探讨注射用甲强龙与头孢替安联合依匹斯汀片口服治疗白细胞升高性急性荨麻疹疗效,为临床制定合理治疗方案提供可参考的依据。方法方便选取并回顾性分析该院门诊及住院部2013年1月—2015年1月治疗的白细胞升高性急性荨麻疹患者80例,随机分为研究组和对照组,每组40例。其中研究组用甲强龙与头孢替安静滴联合依匹斯汀口服;对照组单用甲强龙静滴与依匹斯汀口服,治疗1个周期(4 d)。比较两组疗效前后的是否合并全身症状,皮肤瘙痒程度和皮损面积大小。结果研究组在治疗4 d过程中有效率达到90%,对照组则为47.5%,研究组有效率明显高于对照组,经过统计学处理,差异有统计学意义(P=0.000<0.001)。结论注射用甲强龙与头孢替安联合依匹斯汀口服治疗白细胞升高性急性荨麻没有明显的不良反应,疗效确切,有效率高,有一定的临床应用价值。

Objective To observe the efficacy of methylprednisolone and cefotiam for injection combined with oral medication of epinastine for the treatment of acute urticaria with increase in leucocytes and provide reference for the development of reasonabl clincial therapeutic regimens. Methods Convenient selection 80 patients with acute urticaria with increase in leucocytes who received treatment at the outpetiant and inpatient depapartments of our hosptial from Janurary 2013 to Janurary 2015 were retrospectively analyzed. These patients were divided into research group and control group, 40 cases for each group. The research group was treated with IV drip of methylprednisolone and cefotiam and oral medication of epinastine, while the control group with IV drip of methylprednisolone alone and oral medication of epinastine for one period（four days）. Results During the course of therapy, the effective rate of the research group was 90%, singificantly higher than that of the control group was 47.5%, and statsitical process showed a significant difference between these two groups（P=0.000〈0.001）. Conclusion For the treatment of acute urticaria with increase in leucocytes, methylprednisolone and cefotiam for injection combined with oral medication of epinastine causes no obvious adverse effects, and has an exact effect, high efficiency and certain clinical application value.