碘酊和生物蛋白胶治疗慢性阻塞性肺疾病合并气胸效果对比

The Contrast of Treatment of Chronic Obstructive Pulmonary Disease with Pneumothorax by Iodine and Biological Fibrin Glue

探讨碘酊和生物蛋白胶在慢性阻塞性肺疾病(慢阻肺)合并气胸手术治疗中的临床治疗效果。将85例患者随机分为蛋白胶组(B组)38例,碘酊组(Ⅰ组)31例,对照组(C组)16例。B组患者在术中给予生物蛋白胶封堵肺表面及断面漏气处;Ⅰ组给予碘酊涂擦脏壁层胸膜;C组仅行手术治疗,比较三组治疗效果。Ⅰ组术后第一天胸腔引流液较B组、C组多,漏气时间及带管时间B组和Ⅰ组明显短于C组;术后患者炎性因子白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的浓度Ⅰ组明显高于B组及C组,差异有统计学意义。在慢阻肺合并气胸手术治疗中,应用生物蛋白胶封堵能明显减少术后患者的漏气时间和带管时间,且机体炎性反应明显低于用碘酊涂擦脏层和壁层胸膜者,临床治疗效果肯定。

To observe the treatment of iodine and biological fibrin glue in the pneumothorax surgical which caused by chronic obstructive pulmonary disease, 85 patients were randomly divided into three groups：fibrin glue group （group B） 38 cases, iodine tincture group （group I） 31 cases, 16 cases in control group （group C）. Patients in group B were given biological fibrin glue sealing surface and cross-section flat in operation. Patients in group I plus iodine rubbed the visceral and parietal pleura at the end of surgery; patients in the control group applied surgical treatment only. The authors compared the results of three groups. The patients in group I had more chest drainage fluid than group B and C on the first day after surgery; The patients in group C had longer leakage time and extubation time than the other two groups. The concentration of IL-6 and TNF-α in group I was significantly higher than group IB and C. Biological fibrin glue can be applied in the pneumothorax surgical, which can obviously reduce the patient＇s leakage time and extubation time. Meanwhile, it can reduce postoperative inflammatory reaction obviously.