哌拉西林/他唑巴坦优化给药方案的研究现状及临床合理应用

Outcomes and Rational Clinical Use of Extended or Continuous Versus Intermittent Infusion of Piperacillin/Tazobactam

目的概述哌拉西林他唑巴坦优化给药方案的研究进展,为临床合理应用提供参考。方法检索国内外发表的相关文献,比较哌拉西林/他唑巴坦采用延长输注/持续输注优化给药方案与传统的间歇输注给药方案在生物药效学和临床试验中的差异。结果优化后的给药方案能获得更高的药效学目标,临床疗效和细菌清除率至少不低于传统给药方案。结论优化后的给药方案可以作为合理使用抗菌药物的优选给药方案应用于临床。

OBJECTIVE To introduce the research progress of dosage regimen of piperacillin/tazobactam and its rational offer ref- erence for clinical use. METHODS The domestic and oversea pertinent articles were searched, analyzed and summarized, and the difference between prolonged infusion or continuous infusion and traditional infusionin pharmacodynamics and clinical trials were com- pared. RESULTS The optimized dosage regimen could achieve higher pharmacodynamics goals, with clinical efficacy and bacterial clearance not inferior to the traditional dosage regimen. CONCLUSION The prolonged or continuous infusion strategy should be rec- ommended for piperacillin/tazobactam in the clinic.