正常人及重度OSAHS患者咽腔容积差异性的临床研究

Clinical research of differences of volume of pharyngeal cavity between normal healthy subjects and patients with severe obstructive sleep apnea hypopnea syndrome

目的:探究正常人及重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者手术前后咽腔容积的差异性及对OSAHS患者疗效评估的应用价值。方法:44例健康男性成年人为正常组;38例临床上经睡眠监测确诊为重度OSAHS的患者为实验组,利用咽声反射仪测量正常组和实验组术前及术后3月的咽腔容积、口咽容积、下咽容积,利用多导睡眠监测仪记录实验组术前术后3个月的AHI、阻塞性呼吸暂停次数、最低血氧饱和度并对监测结果进行统计学分析。结果:实验组术后咽腔容积、AHI、阻塞性呼吸暂停次数及最低血氧饱和度均较术前改善(P<0.01)。结论:咽腔容积的测量有助于上气道结构的定量分析,确定狭窄部位、指导术式并可以有效评估手术的疗效。

Objective：To investigate the differences of volume of pharyngeal cavity between normal healthy subjects and patients with severe obstructive sleep apnea hypopnea syndrome（OSAHS）before and after surgery and its application value in assessment of surgical curative effect.Method：Forty-four healthy male adults were included in normal group.Thirty-eight patients with severe OSAHS diagnosed by polysomnography were included in experimental group（OSAHS group）.Volume of pharyngeal cavity,oropharynx and laryngopharynx measured by acoustic pharyngealmetry and AHI,obstructive apnea frequency and the lowest oxygen saturation recorded by PSG monitor were all obtained in normal groups and experimental groups before and 3 months after the surgery.All the data are statistically analyzed.Result：Volume of pharyngeal cavity,AHI,obstructive apnea frequency and lowest oxygen saturation of patients in experimental group were all improved after surgery compared with pre-operation（P〈0.01）.Conclusion：The measurement of pharyngeal cavity volume is helpful to the quantitative analysis of upper airway structure and determine the stenosis location,it is also useful to guide surgery and evaluate the curative effect of the surgery.