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默认网络在阿尔茨海默病早期诊断中的研究进展 被引量：2

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摘要 阿尔茨海默病（Alzheimer＇s disease,AD）是常以情节记忆障碍为首发症状并逐渐进展至全面认知功能减退,伴发精神行为异常,最终导致日常生活能力丧失的中枢神经退行性疾病,是导致痴呆的最常见原因,占痴呆人群的60％ ～70％[1].已有证据表明AD的病理过程始于认知功能障碍出现之前20 ～ 30年[2].
作者 袁宝玉 张志珺
机构地区 东南大学附属中大医院神经内科
出处 《中华神经科杂志》 CAS CSCD 北大核心 2016年第9期729-732,共4页 Chinese Journal of Neurology
关键词 阿尔茨海默病 早期诊断 默认网络 神经退行性疾病 认知功能减退 精神行为异常 日常生活能力 认知功能障碍
分类号 R749.16 [医药卫生—神经病学与精神病学]
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参考文献55

  • 1Burns A, lliffe S. Alzheimer's disease[J]. BMJ, 2009, 338: b158. DOI:10. 1136/bmj, b158.
  • 2Jansen WJ, Ossenkoppele R, Knol DL, et al. Prevalence of cerebral amyloid pathology in persons without dementia [ J ]. JAMA, 2015, 313 (19) : 1924. DOI: 10. 1001/jama. 2015. 4668.
  • 3Albert MS, DeKosky ST, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheimer' s disease : recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease[ J]. Alzheimers Dement, 2011, 7 ( 3 ) : 270-279. DOI : 10. 1016/j, jalz. 2011.03. 008.
  • 4McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer' s disease [ J ]. Alzheimers Dement, 2011, 7 ( 3 ) : 263-269. DOI : 10. 1016/j, jalz. 2011.03. 005.
  • 5Sperling RA, Aisen PS, Beckett LA, et al. Toward defining the preelinieal stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer' s Association workgroups on diagnostic guidelines for Alzheimer's disease [ J ]. Alzheimers Dement, 2011 , 7 ( 3 ) : 280-292. DOI : 10. 1016/j. jalz. 2011.03. 003.
  • 6Dubois B, Feldman HH, Jaeova C, et al. Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria [J]. Lancet Neurol, 2014, 13(6): 614-629. DOI: 10.1016/ s1474-4422 ( 14 )70090-0.
  • 7Buekner RL, Snyder AZ, Shannon B J, et al. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory[J]. J Neurosei, 2005, 25(34): 7709-7717. DOI: 10. 1523/jneurosci. 2177-05. 2005.
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二级参考文献91

  • 1肖世富,薛海波,李冠军,李春波,吴文源,张明园.老年轻度认知功能损害的随访研究[J].中华医学杂志,2006,86(21):1441-1446. 被引量：34
  • 2Zhang ZX, Zahner GE, Roman GC, et al. Dementia subtypes in China: prevalence in Beijing, Xian, Shanghai, and Chengdu. Arch Neurol, 2005, 62: 447-453.
  • 3Wang K, Jiang T, Yu C, et al. Spontaneous activity associated with primary visual cortex: a resting-state FMRI study. Cereb Cortex, 2008, 18 : 697-704.
  • 4Buckner RL, Andrews-Hanna JR, Schacter DL. The brain' s default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci, 2008, 1124: 1-38.
  • 5Johnson JL. Episodic memory deficits in Alzheimer' s disease: a behaviorally anchored scale. Arch Clin Neuropsychol, 1994, 9: 337 -346.
  • 6Mckhann GM, Knopman DS, Chertkow I-I, et al. The diagnosis of dementia due to Alzheimer' s disease: recommendations from the National Institute on Aging-Alzheimer' s Association workgroups on diagnostic guidelines for Alzheimer' s disease. Alzheimers Dement, 2011, 7: 263-269.
  • 7Zang Y, Jiang T, Lu Y, et al. Regional homogeneity approach to fMRI data analysis. Neuroimage, 2004, 22: 394-400.
  • 8Gilbert SJ, Simons JS, Frith CD, et al. Performance-related activity in medial rostral prefrontal cortex (area 10 ) during low- demand tasks. J Exp Psychol Hum Percept Perform, 2006, 32: 45-58.
  • 9Spreng RN, Grady CL. Patterns of brain activity supporting autobiographical memory, prospection, and theory of mind, and their relationship to the default mode network. J Cogn Neurosci, 2010, 22: 1112-1123.
  • 10Bai F, Zhang Z, Yu H, et al. Default-mode network activity distinguishes amnestic type mild cognitive impairment from healthy aging: a combined structural and resting-state functional MRI study. Neurosci Lett, 2008, 438 : 111-115.

共引文献36

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引证文献2

二级引证文献6

中华神经科杂志
2016年 第9期

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