摘要
目的:探讨消癥饮治疗子宫内膜异位症(EMS)疼痛(气滞血瘀证)的疗效及对基质金属蛋白酶(MMP)-3,MMP-9,血管内皮生长因子(VEGF)和肿瘤坏死因子-α(TNF-α)水平的影响。方法:108例患者随机分成对照组(53例)和观察组(55例)。两组均口服孕三烯酮胶囊,2.5 mg/次,2次/周,连续服用6个月。对照组口服散结镇痛胶囊,4粒/次,3次/d。观察组口服消癥饮,每日1剂。两组每月服药28 d,连续治疗6个月,经期不停药。检测治疗前后血清癌抗原125(CA125)和CA199水平,检测治疗前后血清MMP-3,MMP-9,VEGF和TNF-α水平;进行治疗前后疼痛症状、体征评分和子宫内膜异位症生存质量量表(EHP-5)评分。结果:治疗后观察组视模拟(VAS)、痛经、盆腔痛、盆腔压痛、骶韧带触痛结节评分均显著低于对照组(P<0.01);治疗后观察组CA125和CA199水平明显低于对照组(P<0.05);治疗后观察组血清MMP-3,MMP-9,VEGF,TNF-α水平明显低于对照组(P<0.05,P<0.01);治疗后观察组EHP-5量表疼痛、情绪状态、控制感、性生活、不孕和治疗效果评分显著低于对照组(P<0.01);观察组临床疗效总有效率高于对照组(P<0.05)。结论:消癥饮能显著改善EMS患者疼痛,提高患者生活质量,降低血清CA125,CA199,MMP-3,MMP-9,VEGF和TNF-α水平,从而促进疾病的康复。
Objective: To investigate the efficacy of Xiaozheng Yin for the pain in endometriosis( EMS)with Qi stagnation and blood stasis and observe its effects on levels of matrix metalloproteinase( MMP)-3,MMP-9,vascular endothelial growth factor( VEGF) and tumor necrosis factor-α( TNF-α). Method: One hundred and eight patients were randomly divided into control group( 53 cases) and observation group( 55 cases). Patients in both groups took Gestrinone capsules,2. 5 mg / time,2 times / week,continuing for six months. Patients in control group also took Sanjie Zhentong capsule,4 pieces / time,3 times / day,while patients in observation group orally took Xiaozheng Yin,1 dose / day. Both groups took drugs 28 days a month,continuing for 6 months. Medicines were not withdrawn in menstrual cycle period. The levels of serum cancer antigen 125( CA125) and CA199,levels of serum MMP-3,MMP-9,VEGF and TNF-α were detected before and after treatment. Scores of pain,symptoms and endometriosis health profile-5( EHP-5) were graded before and after treatment. Result: After therapy,scores of visual analogue scale( VAS),dysmenorrhea,pelvic pain,pelvic tenderness,and sacral ligament tenderness nodules in observation group were significantly lower than those in control group( P 〈 0. 01).After treatment,levels of CA125 and CA199 in observation group were lower than those in control group( P 〈0. 05),levels of serum MMP-3,MMP-9,VEGF and TNF-α in observation group were less than those in control group( P 〈 0. 05,P 〈 0. 01),the scores of pain,emotional state,control,sexual life,infertility and treatment effects at EHP-5 in observation group were significantly lower than those in control group( P 〈 0. 01). The total effective rate in treatment group was superior to that in control group( P 〈 0. 05). Conclusion: Xiaozheng Yin can obviously improve pain for EMS patients,enhance their quality of life,reduce levels of serum CA125,CA199,MMP-3,MMP-9,VEGF and TNF-α. Therefore,it can promote disease recovery.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2016年第19期126-130,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81473638)