古代医家应用海洋中药海螵蛸临床用药经验模式分析

Clinical Application Experience Mode of Marine Chinese Medicine Sepiae Endoconcha by Ancient Physicians

目的:挖掘海洋中药海螵蛸历代发展所积累的临床用药经验,为海螵蛸的临床应用和研发提供基础。方法:以《中医方剂大辞典》,《中华医典》作为方剂基本信息来源,筛选包含海洋中药海螵蛸方剂,应用频数分析及关联规则挖掘技术和关联网络构建技术进行分析。结果:共筛选方剂721首,涉及中药662味,与海螵蛸配伍频率最高的单味药为龙骨、当归、赤石脂,与鳖甲、附子配合多治疗疟疾,与当归配合治疗带下病;与蒲黄等配合治疗崩漏。关联网络显示,妇科和五官科病症如崩漏、带下病和脓耳等节点聚集性非常高,从混睛障节点的网络关系图可以看出,海螵蛸配伍冰片、白丁香等,以膏剂外用来治疗混睛障。结论:论文挖掘了历代医家积累的海螵蛸在功效主治、临床用量用法、配伍规律等方面的用药经验,补充了对海洋中药的认识,为海洋中药现代临床应用和新药研发提供了参考和基础。

Objective： To mine the clinical medication experience of marine Chinese medicine Sepiae Endoconcha accumulated during the development,in order to build the clinical medication experience mode of Sepiae Endoconcha,and provide the data support for the clinical application and further research of Sepiae Endoconcha. Method： Dictionary of Tradition Chinese Medicine Prescriptions and Encyclopedia of Traditional Chinese Medicine was chosen as basic information sources of formulas. Formulas containing Sepiae Endoconcha were screened,and their information was standardized. Frequency analysis,association rules mining technique and association network building technique were applied to analyze the selected formulas. Result： Totally 721 formulas were screened according to the criteria,involving 662 kinds of Chinese herbal medicines. The most frequently combined medicines with Sepiae Endoconcha were Os Draconis, Angelicae Sinensis Radix and Halloysitum Rubrum. Cuttlebone was usually combined with Trionycis Carapax and Aconiti Lateralis Radix Proeparata to treat malaria,with Angelicae Sinensis Radix to treat leucorrhea,and with Typhae Pollen to treat uterine bleeding.According to the association network,gynecological and ear,nose,throat（ ENT） diseases,such as leucorrhea,pollen typhae and otitis media suppurativa,had very high clusters. According to the network relation map for the node of interstitial keratitis,Sepiae Endoconcha could be combined with camphol and white lilac to treat interstitial keratitis in the dosage form of ointment for external use. Conclusion： According to medication experience in Sepiae Endoconcha’s main efficacies,clinical dosage and usage,and compatibility regularity accumulated by physicians of previous dynasties,this thesis is conducive to supplementing the knowledge of marine Chinese medicine Sepiae Endoconcha,and providing the reference and foundation for the modern clinical application and new drug development of Sepiae Endoconcha