狗皮膏质量分析

Quality Analysis of Goupi Ointment

目的对狗皮膏进行质量分析评价。方法针对高温提取药味进行TLC和显微特征鉴别;针对原粉入药的药味进行GC特征图谱研究和含量测定;应用AA测定家兔贴敷后血铅含量变化;应用UV法测定总羰基化合物含量。结果狗皮膏总体质量状况差,药品质量控制落后,产品质量问题棘手,个别企业未按工艺生产。结论建议:1研究大生产工艺迫在眉睫;2现行标准亟需提高;3限制膏药贴用时间。

OBJECTIVE Analysis the quality of Goupi ointment. METHODS Aiming at the high extraction drugs TLC and microscopic characteristics identification;in the original powder medicine ingredients were determined the GC characteristic spectrum of research and content;AA was used to determine changes in blood lead levels after patching;Determination of total carbonyl compounds content by UV method. Skin cream quality analysis and evalua- tion. RESULTS The overall quality of the species is unsatisfactory due to the following reasons： serious problems were found in the drug production;drug quality control fell behind and some enterprises failed to produce drug according to technological standards. CONCLUSION Specific recommendations： It is critical to research the production process;It is urgent to improve the current control standard;The service life of the patch should be specified.