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右美托咪定复合舒芬太尼在小儿尿道下裂术后镇痛中的临床疗效 被引量:3

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摘要 目的观察右美托咪定复合舒芬太尼在小儿尿道下裂术后镇痛的效果。方法选择本院择期行尿道下裂手术的患儿60例,ASAⅠ~Ⅱ级,患儿均于全身麻醉下行尿道下裂修补术,术毕给予静脉自控镇痛,随机分为3组:S组(舒芬太尼3μg·kg^(-1))、SD1组(右美托咪定2μg·kg-1+舒芬太尼2μg·kg^(-1))、SD2组(右美托咪定2μg·kg^(-1)+舒芬太尼1.0μg·kg^(-1))。观察记录3组患儿术后2h、6h、12h、24h、48h的CHEOPS评分、Ramsay镇静评分及术后48h内PCA按压次数及恶心呕吐、心动过缓、呼吸抑制、过度镇静等不良反应的发生情况。结果 SD2组术后2、6、12、24、48h的CHEOPS评分明显高于S组和SD1组,差异有统计学意义(P<0.05),S组和SD1组术后2、6、12、24h的CHEOPS评分差异无统计学意义。S组术后6、12、24、48h的Ramsay评分显著低于SD1组和SD2组,SD1组和SD2组术后2、6、12、24、48h的Ramsay评分差异无统计学意义。3组患儿48h内均未出现心动过缓,SD2组PCA按压次数显著多于S组和SD1组。结论右美托咪定2μg·kg-1复合舒芬太尼2μg·kg-1用于小儿尿道下裂术后镇痛效果较完善,且不良反应少。
出处 《海峡药学》 2016年第9期132-133,共2页 Strait Pharmaceutical Journal
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