长期稳心颗粒治疗对老年冠心病患者心功能、血管内皮生长因子及心血管事件的影响

Effects of Long-term Wenxin Granules Treatment on Cardiac Function,Vascular Endothelial Growth Factor and Cardiovascular Events in Elderly Patients with Coronary Heart Disease

目的:分析长期稳心颗粒治疗对老年冠心病患者心功能、血管内皮生长因子(VEGF)及心血管事件的影响。方法:选择2012年3月—2015年2月我院收治的76例老年冠心病患者,按就诊或入院顺序编号,均分为对照组与观察组两组,各38例。对照组采用常规西药治疗,观察组加用稳心颗粒治疗,两组均治疗6个月。采用超声心动图监测两组心功能指标左室射血分数(LVEF)、左室收缩末期容积指数(LVED VI)、心脏指数(CI)的变化;监测两组血管内皮指标的变化,检测外周血VEGF、内皮素-1(ET-1)、血栓素B2(TXB2)、一氧化氮(NO)水平;随访6个月,统计两组不良心血管事件发生率。结果:1观察组总有效率为92.11%,高于对照组的60.53%,对比差异有统计学意义(P<0.05);2治疗后,两组LVEF、CI均上升,LVED VI下降,观察组CI、LVEF上升幅度高于对照组,LVED VI下降幅度高于对照组(P<0.05);3治疗后,两组TXB2、ET-1下降,观察组降低幅度高于对照组,两组VEGF、NO上升,观察组上升幅度高于对照组(P<0.05);4随访6个月,观察组各不良心血管事件发生率均低于对照组,但对比差异无统计学意义(P>0.05)。结论:采用稳心颗粒治疗老年冠心病,临床效果显著,可改善患者心功能与血管内皮功能,降低心血管不良事件发生率。

Objective ： To analyze the effects of long-term Wenxin Granules treatment on cardiac function, vascular endothelial growth factor （ CEGF ）and cardiovascular events in elderly patients with coronary heart disease. Methods ： 76 cases of elderly patients with coronary heart disease who were treated in our hospital between March 2012 and February 2015 were numbered according to the order of treatment or admission and were randomized into the observation group and control group two groups, 38 cases in each. The control group was treated with routine western medicine while the observation group was additionally treated with Wenxin Granules. Both of the two groups were treated for 6 months. The echocardiogram was used to monitor the changes of cardiac function indexes [left ventricular ejection fraction （ LVEF ）, left ventricular end systolic volume index （ LVED VI ）, cardiac index （ CI ）] in the two groups; Changes of vascular endothelial indexes in the two groups were also monitored. The levels of peripheral blood VEGF, endothelin-1 （ ET-1 ）, thromhoxane B2 （ TXB2 ）and nitric oxide （ NO ）were detected. After 6 months of follow-up, the incidence of adverse cardiovascular events in the two groups was statistically analyzed. Results： （~）The total effective rate of the observation group （92.11%）was higher than that of the control group （ 60.53% ） （P〈0.05）; ~）After the treatment, LVEF and CI of the two groups increased and LVED VI decreased. The increase of CI and decrease of LVEF in observation group were greater than those in control group. The decreased range of LVED VI was greater than that in the control group （P〈0.05）; After treatment, ET-1 and TXB2 in the two groups decreased, and the decreased range in the observation group was greater than that in the control group. VEGF and NO in the two groups increased. The increased ranges in the observation group were higher than those in the control group （ P〈0.05 ）; In 6 months of follow- up, the incidence of adverse cardiovascular events in the observation group was lower than that in the control group （ P〉0.05 ）. Conclusion ： To apply Wenxin Granules in the treatment of elderly patients with coronary heart disease is with remarkable clinical effect. It can improve the cardiac function and vascular endothelial function, and reduce the incidence of adverse cardiovascular events in patients.