不同胎龄新生儿血清胱抑素C水平的变化

Analysis of the Changes of Serum Cystatin C Level in Different Gestational Age of Newborn

目的:探讨不同胎龄新生儿血清胱抑素C(Cys C)水平。方法:434例新生儿,根据胎龄分为早期早产儿(EPI)组、晚期早产儿(LPI)组、足月儿(FTI)组,分别于生后2 h内(开奶前)采静脉血测定血清Cys C、血清肌酐(SCr)及尿素氮(BUN)水平,并进行组间比较。结果:EPI组Cys C水平略高于LPI组,但差异无统计学意义(P>0.05),EPI组及LPI组Cys C水平高于FTI组(P<0.05);3组间SCr及BUN水平比较,差异无统计学意义(P>0.05)。结论:新生儿血清Cys C水平随胎龄增加而降低,早产儿高于足月儿,Cys C可作为反映新生儿肾功能成熟度的指标之一,其敏感度优于SCr、BUN。

Objective： To investigate serum cystatin C level in different gestational age of newborn. Methods： 434 neonates with different gestational age were divided into various groups： early preterm infant group 146 cases, late preterm infant group 138 cases, full term infant group 150 cases. The lev- els of Serum cystatin C, SCr and BUN were measured within 2 hours after birth （before feeding） and compared. Results： Cys C level of EPI group is slightly higher than LPI group, differences were not statistically significant （ P 〉 0.05 ） , Cys C level of EPI group and LPI group were higher than FTI group （P 〈 0.05 ） ; level of Scr and Bun of 3 groups showed no statistical significance （P 〉 0.05 ）. Conclusion ： The level of Cys decreased with the increase of gestational age, preterm infant was higher than full term infant. Cys C can be used as one of the indicators to reflect the maturity of the renal function in neonates, it is superior to serum SCr and BUN.