盐酸乙哌立松联合舍曲林治疗慢性紧张型头痛疗效

Efficacy of Treatment for Chronic Tension-Type Headache by Eperisone Hydrochloride Combined with Sertraline

目的:观察盐酸乙哌立松联合舍曲林治疗慢性紧张型头痛(CTTH)的疗效及安全性。方法:97例CTTH患者随机分为观察组(50例)和对照组(47例),观察组口服盐酸乙哌立松及舍曲林,对照组单用盐酸乙哌立松;比较两组患者治疗前及治疗4周后的头痛程度(VAS评分)、头痛发作频率、发作持续时间、头痛缓解度、总有效率以及不良反应。结果:治疗4周后,两组对于缓解CTTH均有效,但观察组患者的VAS评分、头痛发作频率、发作持续时间、头痛缓解度及总有效率均优于对照组(P<0.05);观察组4例患者,对照组3例患者出现轻度肢体乏力、嗜睡、头晕及胃肠道反应等不适,两组间不良反应比较,差异无统计学意义(P>0.05)。结论:盐酸乙哌立松联合舍曲林治疗慢性紧张型头痛疗效显著,且安全性好。

Objective： To evaluate therapeutic efficacy and safety of eperisone hydrochloride com- bined with sertraline in treatment for chronic tension-type headache （CTTH）. Methods： 97 patients with CT]FH were collected and randomly divided into observation group （50 cases） and control group （47 cases）. Control group was given eperisone hydrochloride alone, while observation group received eperisone hydrochloride and sertraline at the same time. Compared the headache degree （VAS score） , headache frequency, duration of attack, headache relief degree and total effective rate between the two groups before the treatment and 4 weeks after the treatment. Results： After 4 weeks of treatment, the two groups were effective for the remission of CTTH. But the observation group were better than the control group in the VAS score, attack frequency, duration, pain relief and total effective rate and had statistical significance （P 〈 0.05）. There were 4 cases of observation group and 3 cases of control group patients presented with slight symptoms of weakness with limbs and trunk, lethargy, dizziness, stomach and intestines feedback et al. There was no significant difference between the two groups （P 〉 0.05 ）. Conclusion： Eperisone hydrochloride combined with sertraline is effective and safe to treat chronic tension-type headache.