贵州省黔南地区布依族及汉族中胃癌和胃溃疡患者血清胃蛋白酶原水平

The Research of Serum Pepsinogen Level in Patients with Gastric Diseases in Buyi and Han Groups in Guizhou Qiannan Region

目的:探讨血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)的表达及PGⅠ/PGⅡ(PGR)值在贵州省黔南地区布依族及汉族患者胃部疾病中的意义。方法:选择胃溃疡患者87例(胃溃疡组,布依族42例,汉族45例),胃癌患者43例(胃癌组,布依族20例,汉族23例),非萎缩性胃炎82例(对照组,布依族42例,汉族40例),采用时间分辨荧光免疫分析法检测3组患者血清PGⅠ、PGⅡ的表达,并计算PGR值。结果:胃溃疡组患者血清PGⅠ、PGⅡ水平高于对照组和胃癌组,PGR值低于对照组或高于胃癌组(P<0.05),胃癌组患者血清PGⅠ水平及PGR值低于对照组(P<0.05),胃溃疡组布依族、汉族患者血清PGⅠ、PGⅡ水平高于对照组,布依族胃溃疡组患者血清PGⅠ、PGⅡ及PGR值低于汉族胃溃疡组,但差异无统计学意义(P>0.05);布依族、汉族胃癌组患者血清PGⅠ及PGR值低于对照组(P<0.05),布依族胃癌组患者血清PGⅠ、PGⅡ及PGR值低于汉族胃癌组,但差异无统计学意义(P>0.05)。结论:血清PGⅠ、PGⅡ水平可筛查出是溃疡病的高危人群,血清PGⅠ水平及PGR值水平对贵州省黔南地区胃癌疾病的筛查具有一定的临床意义,PG水平在布依族和汉族间无差异。

Objective： To investigate the expression of serum pepsinogen Ⅰ（PGⅠ ）, pepsinogenⅡ （ PG Ⅱ ） and PG Ⅰ /PG Ⅱ （PGR） ratio, and discuss its clinical significance in patients with gas- tric diseases in Buyi and HaM groups in Guizhou Qiannan region. Method： 87 patients with gastric ul- cer （as gastric ulcer group, including 42 Buyi cases, 45 HaM cases） , 43 cases of gastric cancer （gas- tric cancer group, including 20 Buyi cases and 23 HaM cases, and 82 cases of chronic non atrophic gastritis were selected as control group （ 42 Buyi and 40 HaM cases）. The serum PG Ⅰ and PG Ⅱ were detected by time resolved fluorescence immunoassay, and the ratio of PG Ⅰ / PG Ⅱ （PGR） was calculated. Results： In the gastric ulcer group, the levels of serum PG Ⅰ and PG Ⅱ were higher than control group （ P 〈 0.05 ） , and the level of PG I and PG Ⅱ in the gastric cancer group was lower than control group （P 〈 0.05 ）. Levels of serum PG Ⅰ and PG Ⅰ of Buyi and HaM patients of gastric ulcer group were higher than that of control group, serum PG Ⅰ and PG Ⅰas well as PG Ⅰ/PGⅡvalue of Buyi gastric ulcer group was lower than HaM gastric ulcer group, differences were not statistically sig- nificant （P 〉 0.05 ） ; the Buyi and HaM gastric ulcer patients serum PGI and PG Ⅰ/PG Ⅱ value was lower than that of control group（P 〈0.05）. Buyi gastric cancer group serum PG [ , PG Ⅱ and PG Ⅰ/PG Ⅱ value was value lower than that of the HaM patients in gastric cancer group, the differenceswere not statistically significant （ P 〉 0.05 ）. Conclusion： Serum level of PG Ⅰ and PG Ⅱ could serve to screen out the high risk group of ulcer disease; serum level of PG I and PGⅠ/PG Ⅱvalue had certain clinical significance for the diagnosis of ulcer disease in Guizhou Qiannan region. It points out that there were no differences between the Buyi and Han in PG level.