氟比洛芬酯在甲状腺手术中的应用

Application of flurbiprofen axetil in thyroidectomy

目的探讨氟比洛芬酯治疗甲状腺手术术后头痛的有效性。方法 86例择期行甲状腺手术的患者随机分为2组:对照组(43例):全麻拔管前给予生理盐水,氟比洛芬酯组(43例):全麻拔管前共计给予氟比洛芬酯100 mg。术后24、48 h随访,根据VAS评分(视觉疼痛模拟评分)两次评分均值>4分诊断为术后头痛。结果两组患者术后切口疼痛24、48 h VAS评分比较差异无统计学意义(P>0.05);对照组发生术后头痛10例(23.3%),氟比洛芬酯组发生术后头痛2例(4.7%),两组比较差异有统计学意义(P<0.05)。结论术中应用氟比洛芬酯可以缓解甲状腺手术术后头痛。

Objective To investigate the effect of flurbiprofen axetil on postoperative headache induced by thyroidectomy. Methods Eighty-six patients were divided into two groups randomly. AU the patients underwent general anesthesia, and patients in control group and flurhiprofen axetil group were given sodium chloride injection and flurbiprofen axetil 100 rag. The visual analogue scale （VAS） score was recorded at 24 and 48 h after operation. Postoperative headache was diagnosed when VAS 〉 4. Results There was no significant difference in VAS scores between the two groups at 24 and 48 h after treatment （ P 〉 0. 05 ）. 10 cases （ 23.3% ） of control group, and 2 cases （ 4. 7% ） in flurbiprofen axetil group had postoperative headache, there being significant difference between the two groups （P 〈 0. 05 ）. Conclusion Administration of flurbiprofen axetil during operation can release postoperative headache induced by thyroidectomy.