脑转移肿瘤细胞及其微环境

Tumor Cells and Micro-environment in Brain Metastases

近年来,随着早期诊断的方法的出现及精准治疗的应用,肺癌患者的生存及生活质量都得到很大改善。然而,对于肺癌的脑转移病灶,目前仍缺乏一个理想的治疗方案,严重影响了该部分患者生存状态。了解肿瘤细胞如何在中枢神经系统定植、生长和侵袭等相关生物学行为及其产生机制对预防及治疗肿瘤细胞脑转移病灶具有重大的意义。"种子-土壤"这一假说可以很好的解释这一过程,这一假说的关键即肿瘤细胞可与中枢神经系统微环境各组成之间产生相互适应性变化,正是这种相互作用决定了脑转移病灶的发生发展。本文就脑转移肿瘤细胞、脑转移肿瘤微环境及他们之间的相互作用进行综述,旨在为脑转移病灶的治疗提供新的思路。

Improvements in survival and quality of life of patients with lung cancer had been achieved due to the progression of early diagnosis and precision medicine at recent years, however, until now, treatments targeted at lesions in cen-tral nervous system are far from satisfying, thus threatening livelihood of patients involved. Atfer all, in the issue of prophylaxis and therapeutics of brain metastases, it is crucial to learn about the biological behavior of tumor cells in brain metastases and its mechanism underlying, and the hypothesis “seed and soil”, that is, tumor cells would generate series of adaptive changes to ift in the new environment, is liable to help explain this process well. In this assay, we reviewed documents concerning tumor cells, brain micro-environments and their interactions in brain metastases, aiming to provide novel insight into the treatments of brain metastases.