白细胞介素32与结核病的研究进展被引量：5

Advances in researches of association between interlukin-32 and tuberculosis

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摘要白细胞介素32(interleukin 32,IL-32)是一种潜在性非常高的促炎症细胞因子(cytokine,CK),在很多炎症性疾病中都能检测到它的存在。相关疾病的研究中,其在传染性结核病(tuberculosis,TB)领域的研究于最近几年有一定的进展,有研究表明IL-32与结核病的免疫机制相关。这对于结核病致病机理研究、有效诊断和治疗可能有重要意义。 Interleukine-32 （IL-32） is known as a palingenetic proinflammatory cytokine that has effectively potential value in inflammation. It can be determinated in large amount of diseases with inflammation. In recent years, a great deal of studies on infectious tuberculosis （TB） has achieved a great progress. It has been found that IL-32 is associated with the immunologic mechanism of Mycobaeterium tuberculosis （MTB） infection, which can be of great value for diagnosis and treatment of this pandemic disease in the world.

作者沈龙强梁张赵桂萍柳爱华宝福凯

机构地区昆明医科大学云南省高校热带传染病重点实验室昆明医科大学生物化学与分子生物学系云南省热带病示范型国际科技合作基地昆明市疾病预防控制中心云南省公共卫生与疾病防控协同创新中心昆明医科大学热带医学研究所昆明医科大学病原生物学与免疫学系

出处《中国热带医学》 CAS 2016年第8期833-835,共3页 China Tropical Medicine

基金国家自然科学基金(No.81060134 81371835 31560051 81560596) 云南省自然基金(No.2011FB244 2012FB011 2013FZ057 2014FA011 2014FB001)

关键词白细胞介素32 结核分枝杆菌结核病促炎症细胞因子 Interleukine-32 Myeobaeterium tuberculosis Tuberculosis Proinflammatory eytokine

分类号 R521 [医药卫生—内科学]

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参考文献23

1WHO. Global tuberculosis report 2014[M/OL].[2015-09-24]. http:// apps.who.int/ iris/ bitstream/10665/137094/1/ 9789241564809_eng. pdf?. ua=l.
2MONTOYA D, INKELES M S, LIU P T, et al. IL-32 is a molecular marker of a host defense network in human tuberculosis[J]. Sci Transl Med, 2014,6(250):93-98.
3DAHL C A, SCHALL R P, HE H L, et al. Identification of a novel gene expressed in activated natural killer cells and T cells[J]. J Immuno, 1992,148(2):597-603.
4. KIM S H, HANS Y, AZAM T, et al. Interleukin-32: a eytokine and inducer of TNFc[J]. Immunity, 2005,22(1): 131-142.
5KANG J W, CHOI S C, CHO M C, et al. A proinflammatory cytokine interleukin-3213 promotes the production of an anti-inflammatory eytokine interleukin-10[J]. Immunology, 2009,128(1/2):532-540.
6BAE S, KANG D, HONG J, et al. Characterizing antiviral mechanism of interleukin-32 and a circulating soluble isoform in viral infection [J]. Cytokine, 2012,58(1):79-86.
7CHOI J D, BAE S Y, HONG J W, et al. Identification of the most active interleukin-32 isoform[J]. Immunology, 2009,126(4):535-542.
8KHAWAR B, ABBASI M H, SHEIKH N. A panormnie spectrum of complex interplay between the immune system and IL-32 during pathogenesis of various systemic infections and inflammation[J]. Eur J Med Res, 2015,20(1):1-8.
9. SON M H, JUNG M Y, CHOI S, et al. IL-32 induces chemotaxis of activated T cells via dendritic cell-derived CCL5[J]. Biochem Biophys Res Commun, 2014,450(1):30-35.
10BAI X, SHANG S, HENAO-TAMAYO M, et al. Human IL-32 expression protects mice against a hypervirulent strain of Mycobacterium tuberculosis[J]. Proc Natl Aead Sei USA, 2015,112 (16):51i 1-5116.

二级参考文献36

1张明科,关芬娇,梁朝霞,张娟.结核抗体与痰检结果的比较分析[J].临床肺科杂志,2007,12(5):436-437. 被引量：20
2Kim SH,Han SY,Azam T,et al . Interleukin-32: A Cytokine and inducer of TNFa[ J ] . Iwanunity 2005,22:131-142.
3Dahl CA,Schall RP,He HL,et al . Identification of a novel gene expressed in activated natural killer eells and T cells [J] . J.Immunol 1992,148 : 597.
4Carter KL, Cahir-McFarland E, Kieff E . Epstein-Barr virus-induced changes in B-lymphocyte gene expression [J] . J Virol 2002,76: 10427-10436.
5Park GH, Choe J,Choo HJ,et al. Genome-wide expression profiling of 8-chloroadenosine-and-cAMP-treated human neuroblastoma cells using radioactive human cDNA microarray [J] . Exp Mol Med 2002,34:184-193.
6Brown J,Matutes E,Singleton A,et al . Lymphopain,a cytotoxic T and natural killer cell-associated cysteine ptoteinase [J] . Leukemia 1998,12:1771-1781.
7Coda C,Kanaji T,Kanaji S,et al . Involvement of IL-32 in activation-induced cell death in T cells [J] . International Immunology 2006,18: 233-240.
8Shoda H,Fujio K,Yamaguchi Y,et al . Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases [J] . Arthritis Research & Theraphy 2006,8:R166.
9Beutler B,Jiang Z,Georgel G,et al. Genetic analysis of host resistance: Toll-like receptor signalling and immunity at large [J] . Annu Rev Immunol 2006,24 : 353-389.
10Inohara C,McDonald C, Nunez C . NOD-LRR proteins:Role in hostmicrobial interactions and inflammatory diseases [J] . Annu Rev Bioehem 2005, 74:355-383.