摘要
目的:建立离子色谱法测定奥美拉唑镁原料药中硫酸盐的含量。方法:用Thermo Ion Pac AS19(250mm×4mm)阴离子交换柱和Ion Pac AG19(50mm×4mm)阴离子保护柱,淋洗液:3.6mmol/L碳酸钠和6mmol/L碳酸氢钠溶液,流速:1.0m L/min,柱温:30℃,电导池温度:35℃,阴离子抑制器电流40m A,进样量:25μL。结果:硫酸根酸根离子在0.1~40.0μg/m L范围内线性关系良好(r为0.9996),回收率为100.3%。结论:该方法准确可靠,可用于奥美拉唑镁原料药中硫酸盐杂质的测定。
Objective: to determine the content of sulfate omeprazole magnesium in raw medicine established by ion chromatography.Methods: thermo Ion Pac AS19(50mm×4mm)anion exchange column and Ion Pac AG19(50mm×4mm)anion protective column,eluent:3.6mmol/L sodium carbonate and 6 mmol / L sodium bicarbonate solution and velocity: 1.0m L/min,the column temperature: 30℃,the conductance pool temperature: 35℃,anion suppressor current 40 m A,sample volume: 25μL. Results: The linear range of Sulfate was0.1 ~40.0μg/m L(r =0.9996),the recovery rate was 100.3%. Conclusion: the method is accurate and reliable,and can be used for determination of omeprazole magnesium sulphate impurity in raw medicine
出处
《北方药学》
2016年第10期1-2,共2页
Journal of North Pharmacy
关键词
离子色谱法
奥美拉唑镁
硫酸盐
测定
Ion chromatography
Magnesium sulfate
Determination of Omeprazole