早期梅毒治疗前后的临床及血清学结果探析

Clinical and serological results analysis of early syphilis patients before and after treatment

目的：探讨早期梅毒临床正确治疗方法及治疗前后血清学指标变化情况。方法：2014年1月~2015年12月选取我院收治的早期梅毒患者（n=214）作为本次研究对象,所有患者接受临床对症治疗,记录临床疗效、血清学检验结果变化情况（治疗前、后）。结果：214例早期梅毒经治疗临床总有效率高达93.93%,无效率仅为6.07%;214例早期梅毒经治疗,其TRUST阳性率（2.80%）较治疗前（50.93%）显著降低,治疗前后数据对比差异具有统计学意义（P〈0.05）;但TPPA阳性率（79.44%）则较之前（79.91%）对比无显著差异（P〉0.05）。结论：临床医生应准确掌握早期梅毒临床特点,根据患者实际情况提供针对性的治疗措施,可获得较为理想的临床疗效并显著改善血清学检验结果。

Objective：To investigate the clinical correct treatment method of early syphilis patients and serum indexes changes before and after treatment. Methods：214 cases of old patients with early syphilis treated in our hospital from January 2014 to December 2015 were selected as the objects. Clinical symptomatic treatment were implementated in all patients,recording change of serological test and clinical effect before and after treatment. Results：The clinical total effective and non- effective rates were 93.93% and 6.07%respectively in 214 early syphilis patients after treatment. TRUST positive rate（2.80%）of 214 early syphilis patients after treatment was significantly lower than TRUST positive rate（50.93%） before treatment,there were statistically significant（P〈0.05）. But there was no significant difference in TPPA positive rate（79.44%） compared with TPPA positive rate（79.91%） before treatment（P〈0.05）.Conclusion：Clinicians should accurately grasp the clinical characteristics of early syphilis,select treatment measures according to the actual situation of patients. Thus,it is conducive to obtain a better satisfactory clinical curative effect and improve the serological test results significantly.