加味四妙散联合别嘌醇片治疗高尿酸血症对肾脏损伤延缓效果观察

Delayed Effect of Modified Simiao San Combined with Allopurinol Tablets for Injury of Hyperuricemia on Kidney

目的:观察加味四妙散联合别嘌醇片治疗高尿酸血症对肾脏损伤延缓的效果。方法:选取90例脾肾两虚、湿热内蕴证高尿酸血症患者作为研究对象,分为观察组和对照组各45例。对照组口服别嘌醇片治疗,观察组给予加味四妙散联合别嘌醇片治疗。2组均以30天为1疗程,治疗2疗程。对比2组的疗效,观察血尿酸、血肌酐、尿素氮的变化情况。结果:观察组总有效率为93.33%,对照组为80.00%,2组比较,差异有统计学意义(P<0.01)。治疗2疗程后,2组血尿酸、血肌酐、尿素氮水平均较治疗前下降,观察组3项指标值均低于对照组,差异均有统计学意义(P<0.05,P<0.01)。结论:加味四妙散联合别嘌醇片治疗高尿酸血症能延缓尿酸对肾脏的损伤,提高痊愈的可能性,临床疗效确切。

Objective： To observe the effect of modified Simiao san combined with allopurinol tablets in treating injury of hyperuricemia on kidney. Methods： Selected 90 cases of patients with hyperuricemia as research objects, and divided them into the observation group and the control group according to different therapy methods, 45 cases in each group. The control group was given allopurinol tablets orally, while the observation group was given modified Simiao san combined with allopurinol tablets. 30 days as a course, both group all lasted for 2 courses. Compared clinical effect of two groups and observed level changes of serum uric acid, serum creatinine and urea nitrogen. Results. The total effective rate was 93.33% in the observation group, and was 80.00% in the control group, the difference being significant（P〈 0.01）. After 2 courses of treatment, levels of serum uric acid, serum creatinine and urea nitrogen were decreased comparing with those before therapy, three indexes mentioned above in the observation group were all lower than those in the control group（P〈 0.05, P〈 0.01）. Conclusion：Modified Simiao san combined with allopurinol tablets in treating hyperuricemia can relive its injury on kidney, increase recovery possibility. Adverse responses are slight, its clinical effect and safety are apparent.