抗新生血管药物在增生性糖尿病视网膜病变玻切手术中的应用观察

Application effects of pars plana vitrectomy assisted by anti-vascular endothelial growth factor in the treatment of proliferative diabetic retinopathy

目的研究抗新生血管药物在增生性糖尿病视网膜病变玻切手术中的应用效果。方法选取2015年1月至2015年12月郑州大学第四附属医院收治的60例增生性糖尿病视网膜病变患者,根据治疗措施将患者分为对照组和观察组。对照组采用玻璃体切割术治疗,观察组联合抗新生血管药物治疗,比较两组临床疗效。结果两组患者治疗前、治疗后1个月眼压水平差异无统计学意义(P>0.05);观察组治疗后1、7 d眼压水平显著低于对照组(P<0.05)。观察组视力改善率(96.7%)高于对照组(83.3%),差异有统计学意义(P<0.05)。观察组术后并发症发生率低于对照组(P<0.05)。结论对于糖尿病视网膜病变患者,在玻璃体切割术治疗基础上联合抗新生血管药物治疗效果理想,值得推广应用。

Objective To study the application effects of pars plana vitrectomy assisted by anti - vascular endothelial growth factor in the treatment of proliferative diabetic retinopathy （PDR）. Methods 60 patients （60 eyes） with PDR treated in the Fourth Affiliated Hospital of Zhengzhou University from January of 2015 to December of 2015 were selected. Thirty cases （30 eyes） were treated with PPV （control group）, and thirty cases （30 eyes） were treated with PPV assisted by Anti -VEGF （ob- servation group）. The clinical effects were compared between observation group and control group. Results There was no signif- icant difference in intraocular pressure level between observation group and control group 1 month after treatment. The intraocular pressure level 1,7 days after treatment in observation group was lower than control group. The rate of visual improvement in ob- servation group （96. 7% ） was higher than control group （83.3%）, and the difference was statistically significant （P 〈0.05）. The incidence of postoperative complications in observation group was lower than control group （P 〈 0.05）. Conclusion Effica- cy of pars plana vitrectomy assisted by anti - vascular endothelial growth factor in the treatment of proliferative diabetic retinopathy is ideal and worthy of popularization and application.