甲泼尼龙联合丙种球蛋白治疗小儿重症病毒性脑炎疗效观察

Efficacy of Methylprednisolone Combined With Gamma Globulin in the Treatment of Children With Severe Viral Encephalitis

目的观察甲泼尼龙联合丙种球蛋白治疗小儿重症病毒性脑炎疗效。方法选取我院收治的68例小儿重症病毒性脑炎患儿,随机分组,各34例。对照组采取常规治疗,观察组在对照组基础上给予静注甲泼尼龙与丙种球蛋白治疗,两组均治疗2周,比较两组临床疗效及不良发应发生情况。结果观察组总有效率为97.1%(33/34),对照组总有效率为76.5%(26/34),两组对比差异有统计学意义(P<0.05),且均没有严重不良反应发生。结论应用甲泼尼龙联合丙种球蛋白治疗小儿重症病毒性脑炎可显著提高临床疗效,且较为安全。

Objective To observe the effect of different doses of methylprednisolone combined with gamma globulin in the treatment of children with severe viral encephalitis. Methods 68 cases of children with severe viral encephalitis in our hospital were selected, random grouping, each of 34 cases. The control group was treated with routine treatment, while the observation group was given intravenous methylprednisolone and gamma globulin treatment on the basis of the control group, the two groups were treated for 2 weeks, the clinical efficacy and adverse reactions of the two groups were compared. Results The total effective rate of observation group was 97.1% （33/34）, the control group total effective rate was 76.5% （26/34）, the difference between the two groups was statistically significant （P〈0.05）, and no serious adverse reactions occurred. Conclusion Application of different doses of methylprednisolone combined with gamma globulin in the treatment of children with severe viral encephalitis can significantly improve the clinical efficacy, and more secure.