复发性皮肤坏死性嗜酸性血管炎

A case of recurrent cutaneous necrotizing eosinophilic vasculitis

报告1例复发性皮肤坏死性嗜酸性血管炎。患者男,57岁。全身散在结节、斑块、结痂1个月余。皮肤科检查:面部满布厚黑焦痂,四肢散在同样皮疹,呈圆环状。皮损组织病理检查示:表皮坏死,真皮全层脂肪小叶及间隙内可见大量增生扩张的血管,部分血管壁纤维蛋白样变性,红细胞外溢,伴大量嗜酸性粒细胞、淋巴细胞浸润。诊断:复发性皮肤坏死性嗜酸性血管炎。治疗:口服糖皮质激素联合硫唑嘌呤有效。

A 57-years-old man presented with disseminated nodules, plaques, black thick eschar on his whole body 1 month ago. Skin examination revealed black thick eschar on the face, the same circinal rash on the limbs. Histopathology examination showed epidermal necrosis, a large number of proliferation of the vascular in the whole dermis fat leaflet and interval, fibriuoid degeneration on the wall of some vessels, red blood cell overflow with prominent eosinophilic and lymphocytes infiltrating. A diagnosis of recurrent cutaneous necrotizing eosinophilic vasculitis was made. The lesions improved markedly after treatment with oral glucocorticoid and azathioprine.