半乳糖凝集素-3、可溶性基质溶素-2检测对心力衰竭诊断的相关性研究

Correlation Study of Galectin-3 and Soluble ST2 Levels in Heart Failure Diagnosis

目的:探讨半乳糖凝集素-3和可溶性基质溶素-2(ST2)与慢性心力衰竭分级、传统心力衰竭指标的相关性。方法:选择2014-02至2015-10间在我院心血管内科就诊的慢性心力衰竭患者(慢性心力衰竭组)142例和健康体检人群(正常对照组)85例。按纽约心脏协会(NYHA)心功能分级标准将患者分为Ⅱ级、Ⅲ级、Ⅳ级。入院后完善N末端B型利钠肽原(NT-pro BNP)、高敏C反应蛋白(hs-CRP)、超声形态学等检查,并采用酶联免疫吸附法检测半乳糖凝集素-3、可溶性ST2的表达水平。结果:心力衰竭NYHA心功能Ⅲ级、Ⅳ级患者半乳糖凝集素-3、可溶性ST2明显升高。半乳糖凝集素-3、可溶性ST2与hs-CRP、NT-pro BNP呈正相关,与左心室射血分数呈负相关;可溶性ST2与左心室舒张末期内径(LVEDD)也呈正相关。Logistic分析显示,半乳糖凝集素-3和可溶性ST2与心力衰竭患者近期死亡存在相关性(P<0.05)。半乳糖凝集素-3、可溶性ST2诊断心力衰竭的受试者工作特征曲线(ROC曲线)下面积分别为0.738和0.771,差异有统计学意义(P<0.01)。结论:半乳糖凝集素-3、可溶性ST2与传统心力衰竭指标具有相关性,可用于慢性心力衰竭的诊断。

Objective： To study the correlations between galectin-3, soluble ST2 （sST2） levels and chronic heart failure （CHF） classiifcation, traditional HF indicator and short-term death in relevant patients. Methods： This research included 2 groups： CHF group, containing 142 relevant patients treated in our hospital from 2014-02 to 2015-10 and Control group, containing 85 normal subjects from physical examination at the same period of time. Based on NYHA criterion, the patients were classiifed in NYHA grade II, III and IV respectively. Blood levels of N-terminal brain natriuretic peptide （NT-ProBNP）, high-sensitivity C reactive protein （hs-CRP） and ultrasonic morphology were examined upon admission; protein expressions of galectin-3 and sST2 were assessed by ELISA. Results： The patients with NYHA grade III and IV had increased levels of galectin-3 and soluble sST2; galectin-3, sST2 were positively related to NT-ProBNP, hs-CRP and LVEDD, while negatively related to LVEF. Logistic regression analysis indicated that galectin-3 and sST2 were related to short-term death in CHF patients,P〈0.05. Area under ROC curve of galectin-3 and sST2 for diagnosing CHF were 0.738 and 0.771,P〈0.01. Conclusion： Galectin-3 and sST2 levels were related to traditional HF indicator and could be used for CHF diagnosis in relevant＆amp;nbsp;patients.