乳腺癌内分泌治疗患者焦虑情况与领悟社会支持和生活质量的相关性分析

Analysis of relation between anxiety and understanding social support and living standard during endocrine therapy for breast cancer patients

目的内分泌治疗已经成为乳腺癌综合治疗重要的一部分，NCCN（2015．V2）建议乳腺癌内分泌治疗时间为5～10年，由于治疗时间较长，患者治疗期间心理和生活质量都有可能受影响。通过对接受内分泌治疗乳腺癌患者的现场调研，探讨接受内分泌治疗乳腺癌患者的汉密尔顿焦虑评分、领悟社会支持评分及生活质量评分三者之间的相关性。方法选取174例2009-06-05-2015-03-27在南京医科大学第一附属医院接受内分泌治疗的乳腺癌患者，采用汉密尔顿焦虑评价量表（Hamiltonanxietyscale，HAMA）进行焦虑评估，领悟社会支持量表（perceivedsocialsupportscale，PSSS）进行领悟社会支持力评估，生活质量评价量表SF-36进行生活治疗评估。通过SPSS19．0软件，对3组量表评估数据进行相关性分析。结果患者的HAMA评分为10．24±7．71，具有，临床意义的焦虑症状者，即HAMA≥14分的患者有51例；PSSS评分为68．41±13．63，〈50分的有12例；SF-36评分为113．70±14．82。患者HAMA评分与PSSS评分呈线性负相关关系，R2线性=0．161，R=-0．401，P〈0．05；HAMA评分与SF-36评分，呈线性负相关关系，R2线性=0．186，R=-0．431，P〈0．05。结论HAMA评分分别与PSSS评分、SF-36评分呈负相关关系，应根据焦虑评分状况积极加强对患者的心理干预，抗焦虑治疗，对患者家属进行健康宣教，加强社会支持，对提高，临床治疗效果和患者身体恢复及生活质量水平具有重大意义。

OBJECTIVE Endocrine therapy has become an important part in the comprehensive treatment for breast cancer patients. NCCN （2015. V2） suggested that the period of endocrine therapy of breast cancer should maintain for 5-10 years, therefore, psychology and quality of life of the patients will be affected deeply during the treatment. METHODS By investigating the breast cancer patients receiving endocrine therapy to study the relationship among Hamilton anxiety scale （HAMA） and perceiving social support scale （PSSS） and quality of life score in breast cancer patients, 174 breast cancer patients with endocrine therapy in Department of Breast Surgery were selected in the First Affiliated Hospital of Nanjing Medical University between 2009-6-5 and 2015-3-27,and at the same time were evaluated by HAMA, PSSS and quality of life score. SPSS 19.0 software was applied to analyze the results. RESULTS The average HAMA score was 10.24±7.71. There were 51 patients with ≥14 points of the HAMA score. The average PSSS score was 68.41±13.63 and 12 patients got the score less than 50 points. The average quality of life score was 113.70±14.82. There was a nega- tive correlation between the HAMA score and PSSS score （R2 linear= 0. 161, R = -0. 401, P〈0.05）; HAMA score was negatively correlated with quality of life score statistically （R2 linear= 0. 186, R =- 0. 431, P〈O. 05）. CONCLU- SIONS HAMA score is negatively correlated with PSSS score and quality of life score. Psychological intervention and anti-anxiety treatment should be given based on HAMA score. Health education and social support should also he offered to patients, so as to improve the clinical outcomes, physical recovery and the level of quality of life.